Dai Yong

• Liao S, Ou M, Lai L, Lin H, Zou Y, Yu Y, Li X, Dai Y, Sui W.Integrated analysis of quantitative proteome and transcriptional profiles reveals abnormal gene expression and signal pathway in bladder cancer.Genes Genomics. 2019 Oct 1. doi: 10.1007/s13258-019-00868-w. [Epub ahead of print]
• Dai W, Zhou F, Tang D, Lin L, Zou C, Tan W, Dai Y(Corresponding author).Single-cell transcriptional profiling reveals the heterogenicity in colorectal cancer.Medicine (Baltimore). 2019 Aug;98(34):e16916. doi: 10.1097/MD.0000000000016916.
• Ou M, Li C, Tang D, Xue W, Xu Y, Zhu P, Li B, Xie J, Chen J, Sui W, Yin L,Dai Y(Corresponding author),Genotyping, generation and proteomic profiling of the first human autosomal dominant osteopetrosis type II-specific induced pluripotent stem cells.Stem Cell Res Ther. 2019 Aug 14;10(1):251. doi: 10.1186/s13287-019-1369-8.
• Chen W, Zhuang J, Wang PP, Jiang J, Lin C, Zeng P, Liang Y, Zhang X, Dai Y(Corresponding author), Diao H.DNA methylation-based classification and identification of renal cell carcinoma prognosis-subgroups.Cancer Cell Int. 2019 Jul 16;19:185.
• Tang DE, Dai Y, Lin LW, Xu Y, Liu DZ, Hong XP, Jiang HW, Xu SH.STUB. suppress tumorigenesis and chemoresistance through antagonizing YAP1 signaling.Cancer Sci. 2019 Aug 8. doi: 10.1111/cas.14166. [Epub ahead of print]
• Peng W, Liu S, Meng J, Huang J, Huang J, Tang D, Dai Y(Corresponding author).Profiling the TRB and IGH repertoire of patients with H5N6 Avian Influenza Virus Infection by high-throughput sequencing.Sci Rep. 2019 May 15;9(1):7429. doi: 10.1038/s41598-019-43648-y.
• Fu Y, Li B, Li Y, Wang M, Yue Y, Xu L, Li S, Huang Q, Liu S, Dai Y(Corresponding author).A comprehensive immune repertoire study for patients with pulmonary tuberculosis.Mol Genet Genomic Med. 2019 Jun 7:e792. doi: 10.1002/mgg3.792. [Epub ahead of print]
• Chen W, Zhuang J, Gong L, Dai Y(Corresponding author),Diao H..Investigating the dysfunctional pathogenesis of Wilms' tumor through a multidimensional integration strategy.Ann Transl Med. 2019 Apr;7(7):136. doi: 10.21037/atm.2019.03.37.
• Sun G, Zhu P, Dai Y(Corresponding author), Chen W.Bioinformatics Analysis of the Core Genes Related to Lupus Nephritis Through a Network and Pathway-Based Approach.DNA Cell Biol. 2019 May 15. doi: 10.1089/dna.2019.4631. [Epub ahead of print]
• Zhang R, Ou M, Zhang Y, Yan Q, Chen H, Lai L, Li Y, Xu F, Tang D, Sun X, Dong J, Dai Y(Corresponding author) Sui W.Comparative proteomic analysis of human serum before and after liver transplantation using quantitative proteomics.Oncotarget. 2019 Apr 2;10(26):2508-2514. doi: 0.18632/oncotarget.
• Tang DE, Dai Y, Xu Y, Liu DZ, Hong XP, Ou ML, Jiang HW, Xu SH.The ubiquitinase ZFP91 promotes tumor cell survival and confers chemoresistance through FOXA1 destabilization.Carcinogenesis. 2019 May 2. pii: bgz085. doi: 10.1093/carcin/bgz085. [Epub ahead of print]
• Liu K, Jin H, Guo Y, Liu Y, Wan Y, Zhao P, Zhou Z, Wang J, Wang M, Zou C, Wu W, Cheng Z, Dai Y(Corresponding author).CFTR interacts with Hsp90 and regulates the phosphorylation of AKT and ERK1/2 in colorectal cancer cells.FEBS Open Bio. 2019 Jun;9(6):1119-1127. doi: 10.1002/2211-5463.12641. Epub 2019 Apr 29.
• Ma J, Sun G, Zhu P, Liu S, Ou M, Chen Z, Zou C, Chan FL, Dai Y(Corresponding author), Sui W.Determination of the complexity and diversity of the TCR ß-chain CDR3 repertoire in bladder cancer using high-throughput sequencing.Oncol Lett. 2019 Apr;17(4):3808-3816. doi: 10.3892/ol.2019.10015. Epub 2019 Feb 5.
  
• Lai L, Zhou X, Chen H, Luo Y, Sui W, Zhang J, Tang D, Yan Q, Dai Y(Corresponding author).Composition and diversity analysis of the B-cell receptor immunoglobulin heavy chain complementarity-determining region 3 repertoire in patients with acute rejection after kidney transplantation using high-throughput sequencing.Exp Ther Med. 2019 Mar;17(3):2206-2220. doi: 10.3892/etm.2019.7183. Epub 2019 Jan 17.
• Yue Y, Liu S, Han X, Wang M, Li Y, Huang Q, Li B, Yang M, Dai Y, Fu Y. iTRAQ-based proteomic analysis of human umbilical vein endothelial cells with platelet endothelial aggregation receptor-1 knockdown.J Cell Biochem. 2019 Feb 27. doi: 10.1002/jcb.28494. [Epub ahead of print]
• Liu S, Bi JG, Hu Y, Tang D, Li B, Zhu P, Peng W, Du D, He H, Zeng J, Dai Y(Corresponding author).Targeted next generation sequencing identified novel loss-of-function mutations in MERTK gene in Chinese patients with retinitis pigmentosa.Mol Genet Genomic Med. 2019 Feb 20:e577. doi: 10.1002/mgg3.577. [Epub ahead of print]
• JINGSHENG MA, GUOPING SUN, PENG ZHU2, SONG LIU, MINGLIN OU, ZHIQIANG CHEN, CHANG ZOU, FRANK LEING CHAN, YONG DAI(Corresponding author)and WEIGUO SUI .Determination of the complexity and diversity of the TCR ß-chain CDR3 repertoire in bladder cancer using high-throughput sequencing.ONCOLOGY LETTERS 2019,17: 3808-3816
• Zheng F, Tang D, Xu H, Xu Y, Dai W, Zhang X, Hong X, Liu D, Dai Y(Corresponding author).Genomewide analysis of 6-methyladenine DNA in peripheral blood mononuclear cells of systemic lupus erythematosus.Lupus. 2019 Feb 11:961203319828520. doi: 10.1177/0961203319828520. [Epub ahead of print]
• Liu K, Wang X, Zou C, Zhang J, Chen H, Tsang L, Yu MK, Chung YW, Wang J, Dai Y, Liu Y, Zhang X.Defective CFTR promotes intestinal proliferation via inhibition of the hedgehog pathway during cystic fibrosis.Cancer Lett. 2019 Jan 10. pii: S0304-3835(19)30008-4. doi: 10.1016/j.canlet.2018.12.018. [Epub ahead of print]
• Lei Wang, Yong Dai, Song Liu, Liusheng Lai, Qiang Yan, Huaizhou Chen, Jiaxing Zhang and Weiguo Sui.Assessment of variation in B-cell receptor heavy chain repertoire in patients with end-stage renal disease by high-throughput sequencing.RENAL FAILURE 2019,41(1):1–13 https://doi.org/10.1080/0886022X.2018.1487862
• Chen W, Tang D, Dai Y(Corresponding author), Diao H.Establishment of microRNA, transcript and protein regulatory networks in Alport syndrome induced pluripotent stem cells.Mol Med Rep. 2018 Nov 20. doi: 10.3892/mmr.2018.9672. [Epub ahead of print]
• Diao H, Zhu P, Dai Y(Corresponding author), Chen W.Identification of 11 potentially relevant gene mutations involved in growth retardation, intellectual disability, joint contracture, and hepatopathy.Medicine (Baltimore). 2018 Nov;97(46):e13117. doi: 10.1097/MD.
• Weiguo Sui, Qing Gan, Wei Wei Gong, Xiaolian Wei, Minglin Ou, Donge Tang, Huanyun Jing, Hua Lin, Yue Zhang,  Dai Yong(Corresponding author)Verification of foetal Down syndrome biomarker proteins in maternal plasma and applications in prenatal screening for Down syndrome.Translational Medicine Communications2018;3:9
• Yan Q, Wang L, Lai L, Liu S, Chen H, Zhang J, Dai Y(Corresponding author), Sui W.Next generation sequencing reveals novel alterations in B-cell heavy chain receptor repertoires associated with acute-on-chronic liver failure.Int J Mol Med. 2018 Oct 22. doi: 10.3892/ijmm.2018.3946. 
• Guiqi Yang, Minglin Ou, Huaizhou Chen, Changchun Guo, Jiejing Chen, Hua Lin, Donge Tang, Wen Xue, Wenlong Li, Weiguo Sui and Yong Dai(Corresponding author). Characteristic analysis of TCR ß-chain CDR3 repertoire for preand post-liver transplantation.Oncotarget,  2018 Oct 2;9(77):34506-34519. 
• Wenbiao Chen,Donge Tang, Yong Xu, Yaoshuang Zou, Weiguo Sui, Yong Dai(Corresponding author), Hongyan Diao, Comprehensive analysis of lysine crotonylation in proteome of maintenance hemodialysis patients.Medicine 2018;Sep;97(37):e12035.
• GUOPING SUN, LUMEI QIU, ZHIQIANG CHENG, WEIBING PAN, JINGJUN QIU, CHANG ZOU, NI XIE, SONG LIU, PENG ZHU, JUN ZENG, YONG DAI(Corresponding author). Association of the characteristics of B- and T-cell repertoires with papillary thyroid carcinoma.ONCOLOGY LETTERS  2018,16: 1584-1592
• Song Liu, Ying Zhu, Lie Wen Lin, Shun Kai Ding, Xiao Cong Lin, Ke Li Zhong, Kai Pan, Yong Dai(Corresponding author). The composition and variation of the BCR CDR3s in gastric cancer. Oncology letter, 2018;16,239-246
• Qi, Q Chen, D Xu, N Xie and Y Dai(Corresponding author).Clinical application of protein biomarkers in lupus erythematosusand lupus nephritis.Lupus (2018) 0, 1–9
• Sui W, Gan Q, Liu F, Chen H, Liu J, Dai Y(Corresponding author).The differentially expressed circular ribonucleic acids of primary hepatic carcinoma following liver transplantation as new diagnostic biomarkers for primary hepatic carcinoma.Tumour Biol. 2018 Apr;40(4):1010428318766928. doi: 10.1177/1010428318766928.
• Ou M, Zheng F, Zhang X, Liu S, Tang D, Zhu P, Qiu J, Dai Y(Corresponding author).Integrated analysis of B cell and T cell receptors by high throughput sequencing reveals conserved repertoires in IgA nephropathy.Mol Med Rep. 2018 Mar 20. doi: 10.3892/mmr.2018.8793. [Epub ahead of print]
• Liu S, Pan W, Cheng Z, Sun G, Zhu P, Chan F, Hu Y, Zhang X, Dai Y(Corresponding author).Characterization of the T-cell receptor repertoire by deep T cell receptor sequencing in tissues from patients with prostate cancer.Oncol Lett. 2018 Feb;15(2):1744-1752. doi: 10.3892/ol.2017.7479. Epub 2017 Nov 23.
• Fu Y, Li Y, Xu L, Liu S, Wang M, Xiao L, Liu S, Dai Y(Corresponding author).Immunology repertoire study of pulmonary sarcoidosis T cells in CD4+, CD8+ PBMC and tissue.Oncotarget. 2017 Aug 9;8(52):89515-89526. doi: 10.18632/oncotarget
• Minglin Ou, Weiguo Sui, Ming Yang, Zhen Xiang, Donge Tang, Hua Lin, Yue Zhang, Jiejing Chen, Peng Zhu, Wen Xue, Chengfu Dai, Yong Dai Corresponding author).Novel and low allele frequency variants observed in the exomes of Southern Han ChineseInt J Clin Exp Med 2017;10(11):XXX-XXX  www.ijcem.com /ISSN:1940-5901/IJCEM0057067
• Zheng F, Yu X, Huang J, Dai Y Corresponding author).. Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology.Mol Med Rep. 2017 Sep 27. doi: 10.3892/mmr.2017.7638. [Epub ahead of print]
• Liao W, Li M, Wu H, Jia S, Zhang N, Dai Y, Zhao M, Lu Q.Down-regulation of MBD4 contributes to hypomethylation and overexpression of CD70 in CD4+ T cells in systemic lupus erythematosus. Clin Epigenetics. 2017 Sep 22;9:104. doi: 10.1186/s13148-017-0405-8. eCollection 2017.
• Hong Yuan, Xiao hong Yuan, Donge Tang, Peng Zhu, Weiwei Xiao, Jinghui Ren, Linhua Lin and Yong Dai(Corresponding author).The relationship between serum screening, ultrasound findings, pregnancy history and chromosome abnormalities in cordocentesis: a retrospective report of thirteen years in the South of China. Integrative Molecular Medicine 2017;4(5): 1-6. doi: 10.15761/IMM.1000309
• Ou M, Sun Z, Zhu P, Sun G, Dai Y(Corresponding author).Proteus syndrome: A case report and review of the literature. Mol Clin Oncol. 2017 Mar;6(3):381-383. 
• Lin H, Tan QP, Sui WG, Chen WB, Peng WJ, Liu XC, Dai Y(Corresponding author).Differential proteomics analysis of liver failure in peripheral blood mononuclear cells using isobaric tags for relative and absolute quantitation.Biomed Rep. 2017 Feb;6(2):167-174.
• Sun G, Jia Y, Meng J, Ou M, Zhu P, Cong S, Luo Y, Sui W, Dai Y(Corresponding author).A genetic risk factor for thrombophilia in a Han Chinese family.Mol Med Rep. 2017 Apr;15(4):1668-1672. 
• Sui W, Shi Z, Xue W, Ou M, Zhu Y, Chen J, Lin H, Liu F, Dai Y(Corresponding author).Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology.Oncol Rep. 2017 Mar;37(3):1804-1814.
• Anj Cai,Suwen Qi,Zhuowa Su,Yong Dai(Corresponding author). Method Comparison and Bias Estimation of Blood Urea Nitrogen (BUN), Creatinine (Cr), and Uric Acid (UA) Measurements between Two Analytical Methods.Clinical laboratory 2017;63(1):73-77
• XC Lin, XG Liu, YM Zhang, N Li, ZG Yang, WY Fu, LB Lan, HT Zhang and Y Dai(Corresponding author). Integrated analysis of microRNA and transcription factor reveals important regulators and regulatory motifs in adult B-cell acute lymphoblastic leukemia INTERNATIONAL JOURNAL OF ONCOLOGY 2017 Feb;50(2):671-683.
• X. Hou, J. Chen, L. Wang, Y Dai, H.Diao. Basic research and clinical application of immune repertoire sequencing. 2016(10) 
• Xiaobin Wang, Weiguo Sui, Weiqing Wu,Yong Dai(Corresponding author)Whole genome resequencing of healthy individuals using DNA pooling. Exp Ther Med. 2016 ;12(5):3143-3150.
• S Liu,X Hou,W Sui,Q Lu,Y Hu and Y Dai(Corresponding author).Direct measurement of B-cell receptor repertoire’s composition and variation in systemic lupus erythematosus Genes and Immunity 2017 Jan;18(1):22-27.
• Lin H, Sui W, Li W, Tan Q, Chen J, Lin X, Guo H, Ou M, Xue W, Zhang R, Dai Y (Corresponding author). Integrated microRNA and protein expression analysis reveals novel microRNA regulation of targets in fetal down syndrome. Mol Med Rep. 2016 ;14(5):4109-4118. doi: 10.3892/mmr.2016.5775.
• Lai L, Wang L, Chen H, Zhang J, Wang L, Yan Q, Ou M, Lin H, Hou X, SisiChen, Dai Y(Corresponding author), Sui W. T cell repertoire following kidney transplantation revealed by high-throughput sequencing. Transpl Immunol. 2016 Aug 22. pii: S0966-3274(16)30083-1. doi: 10.1016/j.trim.2016.08.006.
• Donge Tang, Yuyu Chen, Jianrong Huang, Wujian Peng, Kuibi Tan, Honglei Wang, Yong Dai (Corresponding author). Integrated analysis of mRNA, microRNA and protein in systemic lupus erythematosus-specific induced pluripotent stem cells from urine. BMC Genomics 2016 Jul 11;17:488 DOI: 10.1186/s12864-016-2809-9
• Wu H, Huang X, Qiu H, Zhao M, Liao W, Yuan S, Xie Y, Dai Y, Chang C, Yoshimura A, Lu Q. High salt promotes autoimmunity by TET2-induced DNA demethylation and driving the differentiation of Tfh cells.Sci Rep. 2016 Jun 21;6:28065. doi: 10.1038/srep28065.
  

• CPC Shenzhen Committee awarded "Shenzhen new role as the advanced model" in 2018.
• Outstanding medical talents in Shenzhen first Physicians 'Day.
• Prize for the promotion and innovation cooperation of production in China 2014.
• The outstanding talents of America in 2013.
• The Chinese science and technology person(Chinese science award)in 2013.
• Prize of One of "10 elitist Scientist"—By Health, Population and family plan commission of Shenzhen municipality in 2011.
• Young prize-- by Shenzhen municipal goverment in May, 1999.
• Shenzhen Outstanding Young Science and technology expert, City tube outstanding expert in 1997.
• Prize of One of "10 elitist"-- by Shenzhen municipal goverment in 1996.
• Many times was appraised as the hospital advanced worker and the Medical Ethics Noble Award.

Patent registration of P. R. China:

• A method for constructing models and maps of systemic lupus erythematosus.2011; Code: 2011101074297.
• A method for constructing models and maps of rheumatoid arthritis.2011; Code: 2011101075622.
• The Diagnostic Model of Fingerprint of Protein for Systemic Lupus Erythematosus.2008; Code: 200810142501.8.
• The detection method of serum peptides in Kidney graft rejection. 2009; Code: 200910111200.7.
• The stage proteomics different expressed Fingerprint model and construction in systemic lupus erythematosus.2010; Code: 201010223122.9
• A recombinant expression ventor of human pancreatic tissue Kallikrein gene and its Production.2002; Code: 021013538.5.
• A Preparation method of Array-Based Comparative Genomic Hybridization chip for birth defect.2009; Code: 200910111231.9.
• The differentially expressed model and its construction method in HBV infection and alcoholic cirrhosis.2011; Code:201110249195.X.
• The model, construction method and application on differentially expressed patterns of miRNA in the 21st chromosome of Down syndrome. 2012; Code:201210555235.8.
• The analysis method and application on differentially expressed genes in three methylation state of membranous nephropathy.2013; Code:201310076679.8.
• Analysis method and application on different expression of miRNA in renal tissue of primary IgA nephropathy.2013; Code: 201310076687.2.
• Construction and application on ultra-conservative regional transcriptional expression gene model in peripheral blood mononuclear cells of systemic lupus erythematosus.2014; Code:201410093623.8
• The construction and application on ultra-conservative regional transcriptional expression gene model in peripheral blood mononuclear cells of uremia.2014; Code:201410093685.9.
• The constructing method on protemics model of peripheral blood mononuclear cells in respiratory failure.2015; Code:201510431772.5
• The above patents are authorized.
• The methods and application on related miRNA, gene, screening of chromosome 21st in Down Syndrome.2012; Code:201210555209.5
• A constructing method on differentially expressed profile model of long non-coding RNA in monocytes of uremia.2011; Code: 201110181725
• Analysis method and application on differentially expressed genes in the status of hydroxymethyl methylation in systemic lupus erythematosus. (1asp14110021sz).
•  The analysis method and application on differentially expressed genes in the status of Hydroxymethyl methylation of uremia.(2ASP14110022SZ). 
• Analysis method and application on the differential length of non-translation region in 3' end of systemic lupus erythematosus.(Asp15110293sz). 
• construction method and application on Phosphorus proteomics model in hepatocellular carcinoma.(Asp15111236sz). 
• construction method and application on the pathogenic gene model of mental disorder disease.(Asp15111180sz). 
• Construction and analysis on a regulatory network for miRNA and transcription factors in acute myeloid leukemia.(Asp15111593sz). 
• Differential proteomics study of inducible pluripotent stem cells in patients with Alport syndrome.(Asp15111036sz). 
• High-throughput sequencing of T-lymphocyte antigen receptor (TCR) in the CDR3 region explores the diversity of the immune spectrum in SLE.(Asp15111238sz). 
• Analysis of phosphorus proteomics in hepatocellular carcinoma and its regulatory network. (asp15111236sz). 
• The analysis method on model of differentially expressed gene of histone h3k9 three methylation in organ gene.Code: 2013105859549.
• The constructing method on the Atlas model of Down syndrome.Code:201510193659.8.
• A method for the treatment of cyclic RNA in gastric cancer. Code:2016103291563.
• Methods for the treatment of cyclic RNA in systemic lupus erythematosus. Code:2016103271771.
• The processing method of TCR ß-chain complementary decision area. Code:201610317368X.
• Treatment of H-chain CDR3 in B-cell antigen receptor. Code:2016103173622.
• The treatment of ß-chain CDR3 in T cell antigen receptor.Code:2016103163480.
• Screening method on high-contributing pathogenic genes in rheumatoid arthritis. (Asp16112424sz).
• Construction method and construction system on the differential expressed profile model of fetal Origin circRNA of Down syndrome in maternal. (ASP17115003SZ).
• Construction method and construction system on the differentially expressed spectrum model of cyclic RNA in patients with liver transplantation undergoing PLC. (ASP17115004SZ).
• Construction method and construction system on T cell Atlas Model in tissue of bladder cancer. Code:2017105769748
• Construction method and construction system on model of T-cell antigen receptor in patients with acute rejection after renal transplantation. Code:2017105769803
• Screening of maternal fetal origin marker protein in Down syndrome.
• The application on hsa_circrna_102032 in diagnosis, treatment and prognosis of hepatocellular carcinoma.The application on hsa_circrna_102347 in diagnosis, treatment and prognosis of hepatocellular carcinoma. The application on hsa_circrna_103096 in diagnosis, treatment and prognosis of hepatocellular carcinoma.
• The application on hsa_circrna_400031 in diagnosis, treatment and prognosis of hepatocellular carcinoma.
• Construction method and construction system on The differentially expressed profile model of fetal Origin circRNA of Down syndrome in maternal. (ASP17115003SZ).
• Construction method and construction system on model of differentially expressed profile of circRNA in patients with perioperative liver transplantation undergoing PLC.(Asp17115003sz).
• Construction method and construction system on model of differentially expressed profile of circRNA in patients with perioperative liver transplantation undergoing PLC.(Asp17115004sz).
• The application on n6-methyladenine in autoimmune diseases. Code:2018100400733.2.