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Articles

  • Volume: 6, Issue: 1

Apr 28, 2025

Rare Case of Achalasia in Pregnancy

Background: Achalasia, a rare esophageal motility disorder marked by impaired lower esophageal sphincter relaxation and absent peristalsis, presents unique challenges during pregnancy due to risks of dysphagia, aspiration, and nutritional deficiencies. This report highlights a case of achalasia diagnosed during pregnancy, along with an overview of its management and associated implications.

Apr 14, 2025

18-Year-Old Girl with Altered Sensorium and Brain Lesion

Introduction: CNS fungal infections are a rarity and difficult to diagnose. However, with the advancement of technology, fungal brain abscesses are being increasingly diagnosed, especially in immunocompetent patients. Moreover, radiologically, conglomerate abscesses, whether tubercular fungal or parasitic, may look alike. Hence, a multidisciplinary approach involving neurologists, infectious disease experts, neurosurgeons, microbiologists, radiologists, and pathologists increases the chances of...

Mar 17, 2025

Management of Von Willebrand Disease in Pregnancy, During Delivery and Postpartum Period: A Case Report

Von Willebrand Disease (VWD) is an autosomal hereditary disorder characterized by a deficiency or dysfunction of the Von Willebrand factor (VWF), crucial for hemostasis. The disease manifests in three types, with varying degrees of VWF deficiency and function. Managing pregnancies in women with VWD requires meticulous planning due to the increased risk of bleeding complications.

Mar 17, 2025

A Rare Condition Resembling Breast Cancer: Case Report

Introduction: Diabetic Mastopathy (DMP) is an uncommon benign breast condition that affects patients with long-standing type 1 diabetes, presenting a dilemma for clinicians and causing fear for patients due to its resemblance to breast cancer. The interpretation of the imaging results and the attainment of an accurate standard diagnostic remain hypothetical. We reported a case of a woman with Type I Diabetes Mellitus to highlight the radiological findings of this benign breast illness and to en...

  • Volume: 5, Issue: 3

Dec 12, 2024

Clinical Utility of (123) I-MIBG Scintigraphy in Suspected Dementia with Lewy Bodies

A Clinical diagnosis of Lewy Body Dementia (LBD) has low sensitivity (positive predictive values of 34% to 47%). Although Dopamine Active Transporter (DaT) brain scintigraphy is generally useful in suspected LBD, it has a diagnostic sensitivity of only 85%. A normal scan may, therefore, present a dilemma. 123I-MIBG Myocardial Scintigraphy (MIBG) may support diagnosis, but the diagnostic cut-off values are poorly defined.

Oct 31, 2024

Hypersensitivity to Acetylsalicylic Acid or Primary Cutaneous Th2 Cell Lymphoma? Cognitive Autopsy

A 68-year-old male presented with persistent pruritic erythroderma following an acute myocardial infarction, initially suspected to be hypersensitivity to Acetylsalicylic Acid (ASA). Despite the cessation of ASA, the condition persisted, leading to further investigation. Physical examination revealed erythroderma, nail dystrophy, livedo reticularis, and infiltrated hyperchromic lesions. Diagnostic considerations included ASA hypersensitivity, Mycosis Fungoides (MF), and psoriasis. Histopatholog...

Aug 29, 2024

Complex Presentation and Management of Upper Gastrointestinal Bleeding from Aberrant Right Subclavian Artery: A Case Report

Upper gastrointestinal (GI) bleeding is a serious medical condition with various etiologies, including vascular anomalies like an Aberrant Right Subclavian Artery (ARSA) esophageal fistula. ARSA is a congenital anomaly that can lead to rare but life-threatening complications such as severe GI bleeding. This case report details the complex presentation and management of a 27-year-old woman with an ARSA esophageal fistula. Initially presenting with a severe headache and subsequent dural sinus thr...

  • Volume: 5, Issue: 2

Aug 05, 2024

Haemophilus parainfluenzae Associated Pacemaker Lead Infection in an Active Middle-Aged Man

Pacemaker-associated endocarditis is a severe complication typically linked to Gram-positive organisms such as Staphylococcus and Streptococcus. We present a case of an active 59-year-old man with a Haemophilus parainfluenzae associated pacemaker lead infection, a rarely reported occurrence. The patient initially presented with fever, chills, and congestion, and subsequent blood cultures revealed the presence of gram-negative rods. Identification of H. parainfluenzae prompted further investigat...

Aug 05, 2024

Catatonia in the Hidden: A Rare Case of Depressive Disorder

Patients who have catatonia, a motor dysregulation syndrome in which they lose their ability to move normally, are frequently diagnosed with neurological diseases such as encephalitis, stroke, and seizure disorders. Acute medical and neurological diseases, drug usage, mood disorders, and schizophrenia are also associated with it. The underlying ailment determines the intensity of catatonia.

Jul 25, 2024

Successful Desensitization of Trikafta after Hypersensitivity Rash

Hypersensitivity rashes caused by Cystic Fibrosis Transmembrane Regulator (CFTR) modulators are rare, and there is no standard protocol on how to reinitiate the drug after the reaction. A 47-year-old woman with Cystic Fibrosis (CF) developed a maculopapular rash with Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA). Since ELX/TEZ/IVA therapy produced a significant clinical response in the patient, and there is no other therapy that is as effective, we decided to use a slow desensitization protoco...

  • Volume: 5, Issue: 1

Jun 27, 2024

RANBP2 Mutation and Acute Necrotizing Encephalopathy: Case Series

Acute Necrotizing Encephalitis (ANE) is a rare but unique clinical presentation that is associated with morbidity and mortality. A virus-associated febrile illness commonly occurs prior to the onset of ANE, which is then followed by a fast decline in condition. The majority of ANE-reported cases are sporadic. However, there is still a lack of studies focusing on rare familial cases. A strong effort was undertaken to increase public awareness of this condition, as early detection and effective p...

Jun 26, 2024

Extra-Pancreatic Solid Pseudopapillary Epithelial Neoplasm (SPEN) – Case Study

Solid Pseudopapillary Neoplasm (SPEN) is a rare tumor found primarily in the pancreas but can occasionally occur extrapancreatic. We present an unusual case of SPN that arose in the ovaries and subsequently metastasized to the peritoneum in a 13-year-old girl. Histopathological examination showed similarities between the characteristics of ovarian neoplasms and those of pancreatic SPNs.

May 03, 2024

Permanent Pacemaker Implantation in Sick Sinus Syndrome Patient: A Case Report

Sick sinus syndrome is a group of syndromes wherein the patient’s signs and symptoms and an ECG examination are typically used to diagnose the condition. The most common therapeutic approach for bradycardia is the implantation of a permanent cardiac pacemaker. Heart pacemakers have changed from single-chamber, non-programmable devices to dual-chamber, highly programmable devices. A patient with a pacemaker must be closely monitored for the duration of their life to ensure both their safety and ...

  • Volume: 4, Issue: 4

Oct 31, 2023

Dide-Botcazo Syndrome: A Non-Ophthalmologic Blindness

Dide-Botcazo syndrome is an extreme neurological emergency. It is distinguished by bilateral cortical blindness and memory disturbances with anosognosia, which remains a subject of debate if it should be included in the definition. Ischemic stroke of the posterior regions is the main etiology, hence the severity of the visual prognosis in the absence of rapid treatment in the acute phase. We report the case of a patient who has developed the syndrome with bi-occipital ischemia who consulted lat...

Oct 26, 2023

Lipschu¨tz´s Acute Vulvar Ulcer: A Case Report

In 1913, Lipschütz’s ulcers (acute genital ulcers nonsexually related), also known as ulcus vulvae acutum, were originally described by Dr. Benjamin Lipschütz. The etiology still needs to be fully clarified, and in 70% of the cases, it is classified as idiopathic. It is known that these ulcers have a predilection for the labia minora but can also be present on the labia majora or in the perineal region. Vulvar acute ulcers have been mainly associated with viral infections, such as Epstein-Barr ...

  • Volume: 4, Issue: 3

Aug 17, 2023

Classic Macrophage Activation Syndrome Secondary Adult-onset Still’s Disease: Case Report

Adult-Onset Still’s Disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology, characterized by a clinical triad of high spiking fever, arthralgia (or arthritis), and evanescent skin rash. Macrophage Activation Syndrome (MAS) is considered the most severe complication of AOSD. Management of bouth diseases poses several challenges, including difficulty in diagnosis and limited therapeutic options.

Aug 02, 2023

Massive Bilateral Infrapatellar Bursitis: A Rare Manifestation

Background: Bursitis is inflammation and/or swelling of the synovial-lined sac-like structure around joints. A typical presentation would include pain, swelling, and warmth to the bursae, which typically resolves with conservative measures. However, rarely chronic bursitis can mimic more serious conditions, such as synovial sarcomas. This particular case highlights the broad spectrum of how bursitis may present, the importance of distinguishing severe cases of bursitis from sarcomas, as well as...

Jul 28, 2023

Acute Esophageal Necrosis: A Rare and Serious Cause of Digestive Bleeding

Acute Esophageal Necrosis is an uncommon disorder that is assumed to have a multi-factor etiology. We present a case of a 60-year-old man who was admitted to the hospital for the management of diabetic ketoacidosis with cellulitis. Two weeks after the surgical treatment of the abscess, he presented one episode of hematemesis. The upper endoscopy revealed a black mucosa with circumferential necrosis of the esophagus and duodenal ulcers. The patient was managed with supportive care and proton pum...

Jul 04, 2023

Posterior Circulation Ischemic Stroke in a COVID-19 Patient: A Case Report

The SARS-CoV-2 disease is associated with several systemic conditions, including those that comprise the cerebrovascular system. In addition, stroke associated with COVID-19 has been related to multiple immune and non-immune mechanisms leading to thromboembolic and ischemic phenomena. We present the case of an initially COVID-19-antigen-positive female patient with no apparent relevant history attending the emergency department with symptoms of posterior circulation stroke. The patient had a fa...

May 29, 2023

Chromosome 12p12.2p11.22 Deletion in a Patient with Ventricular Fibrillation, Mitral Valve Prolapse, Dilation of Aorta and Intellectual Disability: A Case Report

Interstitial deletion within chromosome 12p is a rare chromosome abnormality. Described clinical phenotypes include short stature, psychomotor delay, microcephaly, brachydactyly, and optic nerve hypoplasia. Here we report a 24-year-old female with 8050 kilobase deletion at 12p12.2p11.22, who has a history of sudden cardiac arrest secondary to cardiac arrhythmia. Cardiac features presented in our case have not been reported in 12p deletion patients.

  • Volume: 4, Issue: 2

May 25, 2023

Erdheim-Chester Disease Clinically Mimicking Omental Carcinomatosis

Erdheim-Chester Disease (ECD) is a rare clonal disorder of the monocyte-macrophage lineage. ECD usually presents as multifocal osteosclerotic symmetric diaphyseal and metaphyseal bone lesions with characteristic epiphyseal sparing in long bones and at least one non-osseous organ involvement. Almost any organ can be involved, but the involvement of the omentum is extremely rare. ECD presentation as an omentum-dominant disease clinically mimicking omental carcinomatosis with the sparing of metaph...

May 10, 2023

Case Reports of Clinical and Histologic Wound Healing Response with Multi-Tissue Extracellular Matrix with Cost Analysis Compared to Negative Pressure Wound Therapy

Introduction: Complex wounds present a clinical challenge to achieve functional restoration. Treatment may involve numerous materials, personnel, and procedures and be expensive. Multi-Tissue Platform (MTP) graft (Xcellistem, Stemsys Bio) is a regenerative Extracellular Matrix (ECM) derived from multiple ECM sources with diverse non-collagenous proteins fibronectin, elastin, and laminin.

Mar 21, 2023

ANCA-Associated Glomerulonephritis Post COVID-19 Infection: Two Case Reports and Review of the Literature

The pathophysiology of renal dysfunction in COVID-19 infection is multifactorial and of high complexity. Myeloperoxidase-antibody-associated glomerulonephritis is a type of glomerulonephritis characterized as a pauci-immune type of necrotizing and crescentic GN. We report two patients who developed ANCA-associated glomerulonephritis shortly after a COVID-19 infection. Both patients, previously healthy and not known with autoimmune diseases, presented with an acute kidney injury after a COVID-19...

Mar 17, 2023

Treatment of a Partially Necrotic Molar Tooth by Applying Apexogenesis Principles

The most suitable endodontic treatments for immature teeth vary depending on the case selection criteria, the dental pulp’s status, the root’s maturity, and the prognosis. This report describes the case of an immature first lower molar tooth with necrotic pulp that was to be treated with the apexification method. During the endodontic procedure, the pulp sensitivity in the apical third of the canal was evaluated as positive. Therefore, the treatment was changed from apexification to modified ap...

  • Volume: 4, Issue: 1

Mar 17, 2023

Occult Cardiac Amyloidosis: “One-Stop Shop” Pre-procedural Cardiac Computed Tomography on Catheter Ablation in Atrial Fibrillation

A 79-year-old man with Atrial Fibrillation (AF) underwent Computed Tomography (CT) imaging using a 320-detector row CT scanner for catheter ablation planning. A comprehensive assessment scan protocol consisting of two electrocardiography-gated cardiac acquisitions was used. The early (first) phase imaging indicated that the patient was anatomically suitable for a catheter ablation procedure and had no significant stenosis with moderate coronary artery calcification but showed a contrast-filling...

Feb 16, 2023

Late Infection of Total Knee Arthroplasty Associated with Aortoenteric Fistulae

Prosthetic joint infection is an undesired complication following primary arthroplasty. Bacterial arthritis of the ankle following an aortoenteric fistula has been previously reported. However, to the best of our knowledge, there are no reports of Prosthetic Joint Infection (PJI) associated with bacteremia due to a Secondary Aortoenteric Fistula, as in this case report. Although rare, Secondary Aortoenteric Fistula should be considered when treating a prosthetic joint infection after aortic rec...

Jan 13, 2023

Ketamine Infusion for Pain Management in a Case of Thoracic Outlet Syndrome

This case report presents the successful use of ketamine infusion therapy as pain relief for a patient with bilateral neurogenic Thoracic Outlet Syndrome (TOS) combined with arterial TOS after bilateral first rib resection surgery. The patient did not respond well to medical management due to limited effects and severe side effects. However, surgical treatment resulted in temporary relief. After ketamine infusion, quality of life has improved considerably because of increased functional capacit...

  • Volume: 3, Issue: 8

Nov 16, 2022

Gonococcal Conjunctivitis due to Non-Sexual Transmission in a One-Year-Old Infant

An eighteen-month-old infant with ocular secretion and edema in one eyelid was taken to the Emergency Pediatric Unit. The laboratory analysis identified Neisseria gonorrhoeae in the ocular secretion, and treatment with third-generation cephalosporin was administered, with a favorable outcome. During the infant’s hospitalization, her mother was diagnosed with pelvic inflammatory disease.

Nov 02, 2022

Are Red Stools after Red Dragon Fruit (Selenicereus costaricensis) Ingestion a Red Herring? – Case Report and Clinical Pearls for Recognition

Haematochezia is the most common presentation of lower gastrointestinal bleeding and is a frequent diagnosis resulting in admission or outpatient attendance to gastroenterology and colorectal services. We report the first case of hospital admission with a benign presentation of blood-red stools following red dragon fruit ingestion and details of his evaluation, including biochemistries and endoscopy. We review the available literature regarding the fruit and betacyanins and offer clinical pearl...

Nov 01, 2022

Solitary Fibrous Tumor of the Breast, a Rarity: A Case Report and Review of Literature

Solitary Fibrous Tumors (SFT) are rare fibroblastic mesenchymal neoplasms that most often arise from the visceral pleura, abdomen/pelvis, extremities, and neck. However, SFTs have been reported at any anatomical site. Solitary fibrous tumors occurred in patients over a wide age range with a median age of 60 years. Most SFTs have an indolent course, but 11% to 22% of the SFTs show a more aggressive behavior with distant metastasis and malignant transformation.

Oct 17, 2022

A Rare Case of Bilateral, Sequential Orbital Myositis as an Extra-intestinal Manifestation of Crohn’s Disease

Crohn’s Disease (CD) is a complex inflammatory disease of the gastrointestinal tract, which is often associated with Extra-Intestinal Manifestations (EIMs). The estimated prevalence of ocular manifestations in patients with CD is 3.5%–6.8%, with uveitis, episcleritis, and scleritis comprising most of these cases. Orbital Myositis (OM) is an exceedingly rare ocular EIM which has also been reported. We present a case of a 22-year-old female patient with CD on ustekinumab monotherapy in clinical r...

Oct 11, 2022

Vaccine-Induced Oral and Perioral Swelling, Paresthesia, and Xerostomia

Oral health is a source of psychological and physical comfort. A 59-year-old male patient presented five weeks after receiving the first dose of the Pfizer COVID-19 vaccine. He experienced physical and psychological distress, anxiety, fear, and pain from perioral swelling, cracked lips, numbness, and xerostomia. These signs and symptoms negatively affected his smile and overall facial expression. His condition worsened over time and included dryness around the mouth and chapped lips. Within fou...

  • Volume: 3, Issue: 7

Oct 10, 2022

Mastectomy for Severe Radiation-Induced Fibrosis Following Breast Conservation Therapy

Breast conservation therapy with excision and adjuvant radiation has become an acceptable alternative to mastectomy in treating early-stage breast cancer. This report of a case of severe radiation-induced fibrosis following breast conservation therapy serves to inform the oncologic community of the multimodal approach to non-operative management of radiation-induced fibrosis and indications for surgery in the treatment of this complication arising from external beam radiation.

Oct 10, 2022

Low-aggressive Long-term Continuous Hyperthermia in Combination with Extremely Low-Dose Chemotherapy for Prostate Cancer Patients at Medoc Health Clinic in Japan

According to the patient’s wishes, hyperthermia is an adjuvant therapy with an image as a treatment option; however, facilities that can provide this treatment are limited. We prioritize patients’ wishes at our hospital. Herein, we report the current situation along with reports of five patients who were treated with hyperthermia combined with extremely low-dose chemotherapy with in over 6 years. Five patients in their range of 42 years–72 years were histologically diagnosed with prostate cance...

Sep 08, 2022

Splenic Infarct following COVID-19 mRNA Vaccine: Is it Crohn’s or Vaccine-Induced Immune Thrombotic Thrombocytopenia?

Reports of thrombosis post-Coronavirus disease 2019 (COVID-19) vaccine have raised safety concerns. Report a rare case of possible vaccine-induced immune thrombotic thrombocytopenia diagnosed after the Pfizer vaccine in a Crohn’s disease patient who had been advised to discontinue his combination treatment (adalimumab plus azathioprine) before vaccination to improve antibodies response. Evidence-based medical advice by physicians remains crucial in vaccination campaigns.

Sep 07, 2022

Diagnosis of Multisystem Inflammatory Syndrome in Children with Gastrointestinal Manifestations

Improving survival for children with cancer has been attributable to the provision of intensive therapies (i.e., high-dose chemo/radiotherapy and Hematopoietic Cell Transplantation-HCT). However, as a result of these treatments, most children suffer and experience severe and distressing treatment-related symptoms such as taste and smell alterations that can hamper the quality of life of these patients by influencing their appetite, body weight, and psychological well-being. In addition, one of ...

Sep 06, 2022

Biologics for Severe Asthma in Elderly Patients with Chronic Kidney Disease and Cirrhosis: A Case Report

Background: In recent years, several new biologics, such as benralizumab has been developed to treat patients suffering from asthma poorly controlled by high-dose Inhaled Corticosteroids (ICS) and long-acting bronchodilators. Benralizumab is a humanized, interleukin (IL)-5Ra-specific monoclonal antibody that effectively ameliorates asthmatic episodes by inducing rapid and nearly complete depletion of eosinophils.

  • Volume: 3, Issue: 6

Aug 03, 2022

Traumatic Iris Cyst Treated with YAG Laser: A Case Report

We report a clinical case of an 8-year-old with a history of penetrating trauma in the right eye. Surgical innervation was performed due to a corneo-limbo-scleral wound. After one year, he presented to our department with decreased vision and discomfort in the right eye. Upon examination, a traumatic iris cyst is observed. The cyst was treated with Nd-YAG laser, obtaining a size reduction and visual acuity improvement.

Aug 02, 2022

Histiocytosis X: A Case Report of Langherans Cell Histiocytosis with the 3D Surgery

Background: Langerhans Cell Histiocytosis (LCH) is a relatively rare disorder with a strong inflammatory component. It has diverse clinical manifestations, which range from a single lesion or multiple bony lesions to severe multi-system involvement. Approximately 10% to 20% of cases of LCH occur in the jaw, with the posterior mandible being the most frequently involved site. The majority of patients are children younger than three years, and the incidence in adults is approximately 1-2/million....

Jul 07, 2022

The Association between Vasospasm and Serum Concentrations of Aldehyde Dehydrogenase 2 in Patients with Variant Angina

Background: Vasospastic angina is caused by vasospasm of the coronary arteries. Aldehyde dehydrogenase 2 (ALDH2) is involved in nitroglycerin metabolism and reduces oxidative stress, thereby suppressing vasospasm. However, it is unclear whether a change in the expression level of human ALDH2 in the blood correlates with the regulation of vasospastic angina.

Jun 28, 2022

Plasma Cell Gingivitis Associated with the Pfizer-BioNTech COVID-19 Vaccine: A Case Report

Anaphylactic reactions to the Pfizer-BioNTech mRNA vaccine may occur, but their etiology is unclear. We are suspicious of a possible link between the first dose of the Pfizer vaccine and generalized gingival inflammation associated with hyperemic, erythematous gingival enlargement that was noticed one week after vaccination. The patient was a breastfeeding woman who presented with a chief complaint of a sudden change of normal pink gum tissue to fiery red, swollen, and bleeding one week after r...

  • Volume: 3, Issue: 5

Jun 23, 2022

Five Rare Abdominal Wall Hernias in One Patient: A Case Report

Diagnosing abdominal wall hernias remains challenging due to the occurrence of multiple symptoms. Only a few reports have been published describing the combination of rare abdominal wall hernias. We report the case of a 69-year-old woman with abdominal pain lasting three days. During diagnostic imaging using a CT scan, seven abdominal hernias were discovered. Although all individual hernias have been reported before, the combination of an umbilical hernia; a left femoral hernia; a bilateral hig...

Jun 23, 2022

Early Onset of Aggressive Primary Cutaneous CD8+ Gamma-Delta T-Cell Lymphoma at Young Female Patient with Hemophagocytic Syndrome and Fatal Pilocytic Astrocytoma Cerebellar Involvement

Introduction: Primary cutaneous gamma-delta T-cell lymphoma (PCGD-TCL) is a rare lymphoma that accounts for 1% of all cutaneous T-cell lymphomas. The average age at onset of the disease is 42 years. We present a cutaneous gamma-delta T-cell lymphoma case in a 26-year-old patient with hemophagocytic syndrome and simultaneous cerebellar pilocytic astrocytoma manifestations.

Jun 21, 2022

Safety of Re-Vaccination after Developing Urticaria at the First Dose of Chadox1 nCov-19

The World Health Organization (WHO) approved the AstraZeneca/Oxford COVID-19 vaccine (ChAdOx CoV-19) for emergency use in February 2021. The WHO’s Strategy Advisory Group of Experts on Immunization recommended use for all age groups 18 and above. However, after the ChAdOx CoV-19 vaccine rollout, allergic reaction following ChAdOx CoV-19 vaccination was reported, causing vaccine hesitancy. Although a heterologous prime-boost strategy could be used in those who have had such an allergic reaction,...

Jun 17, 2022

Pulmonary Light Chain Disease: An Unusual Presentation in a 54-Year-Old Man with Pulmonary Cysts and Granulomatous Inflammation with Localized Vasculitis

A 54-year-old asymptomatic male with a ten-year history of a left lung nodule presented after a follow-up chest scan showed an increased nodule size and multiple perivascular cysts. Histopathological examination showed necrotizing, granulomatous inflammation with neutrophils, eosinophils, lymphocytes, and plasma cells, with surrounding vasculitis; another section showed accumulation of amorphous, eosinophilic material without granulomas or vasculitis. This case was initially broadly classified ...

  • Volume: 3, Issue: 4

Jun 17, 2022

Pancreatic Solid-Pseudopapillary Neoplasm in an Adolescent Girl Presenting as an Acute Abdomen

A rare clinical case of the pediatric solid-pseudopapillary tumors of the pancreas is described. The diagnostic techniques and the choice of surgical procedures and adjuvant chemotherapy, using own experience, are presented. In addition, the literature data that reveal many novelties regarding the complications and the exodus of the disease is discussed.

May 27, 2022

Retinitis Pigmentosa 45: A Case Report

Clinical case of a 36-year-old man with symptomatic peripheral visual field loss. Electroretinography showed severely reduced rod function. The DNA test revealed homozygous deletion mutation in CNGB1, associated with Retinitis Pigmentosa type 45, characterized by an early onset with a rather slow progression of the disease.

May 20, 2022

Omalizumab-Adjuvanted Desensitization to Comirnaty® in a Patient with Previous PEG Anaphylaxis

Vaccines against Sars-CoV-2 (Severe acute respiratory syndrome coronavirus 2) have demonstrated a crucial role in overcoming the Covid-19 (coronavirus disease 2019) pandemic, and a worldwide vaccination campaign has started at the end of December 2020. However, those subjects who exhibit contraindications to vaccines are at risk of remaining excluded from immunization. A severe allergy to a vaccine or a vaccine component represents such a condition. Nevertheless, an accurate allergological eval...

May 20, 2022

Hypokalemic Periodic Paralysis: A Case Report

Introduction: Hypokalemic periodic paralysis (HPP) or Westphall’s disease is a genetic channelopathy with autosomal dominant transmission at the origin of transfer hypokalemia. We report the first observation of a Malagasy patient in Madagascar to incite physicians to evoke it in front of an association of hypokalemia and a neurological deficit.

  • Volume: 3, Issue: 3

May 09, 2022

Cemiplimab: A Breakthrough Therapy for Advanced Cutaneous Squamous Cell Carcinoma

Cutaneous Squamous Cell Carcinoma (cSCC) is the second most common type of skin cancer, characterized by the uncontrolled proliferation of keratinocytes. Treatment options depend on the stage of the disease, with systemic therapy reserved for locally advanced and metastatic disease. Cemiplimab, an anti-PD 1 monoclonal antibody, has proven efficacy against this highly immunogenic tumor, increasing evidence of its usefulness in unresectable, metastatic, and locally advanced diseases.

Apr 19, 2022

Treatment of Postoperative Non-Healing Wound with Fire Needle Therapy: A Case Report

Case summary: A 67 elderly female patient suffered from a postoperative non-healing wound after craniocerebral trauma surgery, and effective debridements and local anti-infection therapies were tried, but the effectiveness was limited. An adapted fire needle therapy was tried. The fire needle therapy used was divided into two stages. In the 1st stage, a thick fire needle was used once a day for four days, four times total. During the 2nd stage, a thin fire needle was adopted once every other da...

Apr 06, 2022

Fatal Intracerebral Abscess and Pseudo-Meningocele Following Craniotomy

A 65-year-old male smoker with a history of hypertension presented to the emergency department with a two-day history of slurred speech and left-sided hemiplegia followed by a status epilepticus. After initial resuscitation, requiring mechanical ventilation and anticonvulsants, a head Computed Tomography (CT) scan was performed and showed an approximately 4.5 cm enhancing right frontal intra-axial tumor complicated by diffuse perilesional edema and a mass effect on median structures (Figure 1A)...

Mar 31, 2022

Smiling at Low Cost: An Alternative to Traditional Vestibuloplasty

A 60-year-old patient presented for complete maxillary and mandibular dentures following extractions and alveolar bone remodeling. However, once the extractions and alveoloplasty were complete, the lack of depth or width of the alveolar ridge precluded the placement of a quality mandibular denture following the conventional protocol. A modified treatment technique was therefore created to enable a complete mandibular denture. A full-thick flap had been laid from mandibular premolar to premolar,...

  • Volume: 3, Issue: 2

Mar 02, 2022

Metastatic Ovarian Cancer Mimicking a Primary Rectal Cancer: A Case Report

Colorectal cancer (CRC) is a common type of malignancy. However, metastatic CRC is rare and difficult to diagnose. We present a case of metastatic ovarian cancer mimicking primary rectal cancer. Our 76-year-old patient was diagnosed via immunohistochemical staining of an endoscopic biopsy sample and underwent surgery for low anterior resection and Hartmann’s procedure. With acceptable results, this was followed by chemotherapy based on cisplatin and paclitaxel regimens for ovarian carcinoma wit...

Feb 25, 2022

Unusual Delayed Pulmonary Presentation of Carbon Monoxide Poisoning: A Case Report

Carbon monoxide (CO) poisoning causing lung parenchymal damage is uncommon. We illustrate a case of a 27-year-old gentleman with a recent history of self-inhalation of CO who, following an uneventful recovery, presented with acute cardiorespiratory symptoms and was subsequently diagnosed with inhalational pneumonitis. We describe the case with delayed complications pertaining to the respiratory system and its likely pathogenesis. Obtaining an accurate exposure history is key to identifying the ...

Feb 24, 2022

Palatal Lesions of Reactive Arthritis Triggered by a New Coronavirus: A Case Report

Background: The available scientific data on the oral manifestations of the new coronavirus is contradictory. Some scientists report that the oral and nasal mucosa is particularly affected during SARS-CoV-2 infection. However, others report infrequent involvement of the oral mucosa. Unlike oral lesions, orofacial symptoms such as anosmia/hyposmia and/or ageusia/dysgeusia/hypogeusia are better documented. We want to describe oral lesions in a patient with confirmed SARS-CoV-2 infection and assoc...

Feb 22, 2022

An Electrophysiological Investigations of the Human Triceps Surae Muscle after a Simulated Microgravity Environment

This paper compares the effects of 7-day “dry” water immersion (DI) and intermittent muscle contractions on electrical and mechanical failure during muscle fatigue in the human Triceps Surae (TS) muscle electrically stimulated at 50 impulses s-1 via its motor nerve. 1-s intervals separated intermittent contractions of 60-s duration for the identical duration of tension development. The 60-s intermittent contractions decreased tetanic force to 57% (p < 0.05) of initial values, but force reductio...

Feb 14, 2022

Conservative Management of Large Spontaneous Vaginal Hematoma in the Puerperium

Spontaneous occurrence of pelvic floor hematoma is not common, and there is no specific figure in literature for its incidence. Most cases of pelvic hematomas arise from bleeding lacerations following operative deliveries or episiotomies; therefore, a high index of suspicion is needed when a patient presents with excessive perineal and back pain following a normal vaginal delivery as early detection of puerperal hematomas prevents morbidity and mortality. Most cases of large vaginal hematomas a...

  • Volume: 3, Issue: 1

Feb 11, 2022

Combined Picosecond Laser Tattoo Removal with an Acoustic Shock Wave Device: A Case Series

Optimal laser tattoo removal in fewer sessions has been consistently investigated. As a result, dermatologists and laser surgeons have been leading the way to develop techniques and methods to remove tattoos in the fastest and safest possible way effectively. Acoustic Shock Wave Therapy has been recently described as an adjuvant in enhancing tattoo clearance by increasing lymphatic drainage and increasing metabolic activity in the treated area, thereby accelerating the clearance of dermal pigme...

Feb 07, 2022

Adnexal Torsion during Childhood: A Case Report

Adnexal torsion sometimes causes diagnostic challenges, mainly in a pediatric patient and when it lacks an ovarian tumor. For four days, a 9-year-old girl presented to the medical service complaining of right lower abdominal pain. Laboratory data showed mild leukocytosis and an elevated C-reactive protein. Abdominal ultrasound showed an enlarged right ovary measuring 57 mm x 38 mm. A pelvic computed tomography showed a small amount of free fluid in the peritoneal cavity. These data suggested an...

Jan 21, 2022

False Positive Uptake of I-131 in a Case of Hemangioma Mimicking as Bone Metastasis

Thyroid carcinoma is treated by near-total or total thyroidectomy, followed by 131Iodine (131I) ablation of any remnant thyroid tissue. 131Iodine whole-body scan (WBS) has been used for the follow-up of differentiated thyroid carcinoma for several decades. The specificity of the 131I whole-body scan for detecting residual, metastatic, and recurrent differentiated thyroid carcinoma is reported to be higher than 90%. However, radioiodine uptake is not specific to thyroid tissue. It could also be ...

Jan 17, 2022

A Case of Severe Liver Injury as Part of DRESS Syndrome due to Minocin

ackground: Minocin is an antibiotic used in the treatment of adolescent acne. Overall, Minocin is considered safe and effective with proper usage. As its use has increased, more severe reactions have been identified, including anaphylaxis, lupus-like syndrome, hypersensitivity syndrome reaction (DRESS syndrome), and hepatitis. In this paper, we present the case of a 17-year-old Jewish female who presented with fever, pharyngeal pain, rash, and elevated transaminases; her medical history was ...

Jan 10, 2022

A Therapeutic Approach to Hormone Receptor Positive Metastatic Breast Cancer in a Young Female Patient

Hormone receptor-positive breast cancer is the most common subtype in women. Endocrine therapy is the recommended first-line therapeutic approach as research shows that it has the highest efficacy in managing carcinoma. Our case presents a 28-year-old female patient diagnosed with left hormone receptor-positive breast cancer that had metastasized to her bones, lymph nodes, and liver. Due to her increasingly adverse condition, chemotherapy was used as a first-line treatment, followed by endocrin...

  • Volume: 2, Issue: 8

  • Volume: 2, Issue: 7

Dec 31, 2021

Neuromyelitis Optica Spectrum Disorder (NMOSD): Pseudo Vascular Presentation

Introduction: Myelitis in Neuromyelitis Optica spectrum disorder can have an abrupt onset. Observation: A 17-year-old woman presented March 17, 2017 brutal tetraplegia associated with vesical sphincteric disorders with no history, preceded by intense interscapulum pain. The neurological examination objected to a flaccid muscle deficiency of the four limbs. Medullar MRI showed a hyperintensity on T2 from C2 to D2 with “Snake eye” in the axial view. The diagnosis of medullary ischemia was held...

Dec 30, 2021

Primary Hepatic Choriocarcinoma

Primary choriocarcinoma of the liver is a rare malignant tumor derived from trophoblast cells or pluripotent hepatocytes. Its main hallmark is ß-HCG increased significantly. It occurs in older men very rarely and has a poor prognosis. Choriocarcinoma is a kind of malignant tumor that originated from trophoblast cells or pluripotent stem cells. It mostly occurs in the gonad with a high degree of malignancy and poor prognosis. Choriocarcinoma usually occurs in infants and women after pregnancy, w...

Dec 30, 2021

A Case of Pemphigus Vulgaris in a Patient with Primary Hypogammaglobulinemia

Pemphigus Vulgaris (PV) is a rare autoimmune disorder characterized by the presence of blisters on the mucous membranes and skin. Autoimmunity is a crucial complication developing in Predominantly Antibody Deficiencies (PADs), a subgroup of Primary Immunodeficiencies (PIDs). Herein, we present a case with PV who had PAD and whose disease relapsed in the maintenance period of conventional immunosuppressive treatments but was promoted to remission by high-dose Intravenous Immunoglobulin (IVIG) th...

  • Volume: 2, Issue: 6

Dec 30, 2021

Mechanobullous Epidermolysis Bullosa Acquisata in a Patient with Underlying Systemic Lupus Erythematosus

Classical/mechanobullous Epidermolysis Bullosa Acquisita (EBA) presents with acquired fragility, trauma-induced blistering, milia, and scarring. Bullous SLE BSLE is an inflammatory disease with neutrophil-rich blisters on sun-exposed sites. We present a rare case of chronic SLE who developed an acquired immunobullous disease with clinical features of EBA rather than BSLE.

Dec 30, 2021

Ruptured Heteroptopic Pregnancy: A Surgical Emergency with an Uncommon Cause

Spontaneous heterotopic pregnancy is a rare condition and can present with signs of hypovolemic shock due to rupture. A 31-year-old woman presented in the emergency department with lower abdominal pain with signs of peritoneal irritation and hypovolemic shock. She was eight weeks pregnant via spontaneously conceived intrauterine pregnancy confirmed on an ultrasound scan. Her past medical history was significant for a C-section 2 years ago. Initially managed in the resuscitation room in ED, she ...

Dec 29, 2021

Feasibility of Cardia-Preserving Proximal Gastrectomy to Treat the Early Gastric Cancer of Upper Third of Stomach

Background: Cardia-preserving proximal gastrectomy (CPPG) is a function preserving surgery for treating early gastric cancer (EGC) of the upper stomach, which aims to reduce the incidence of complications and improve the quality of life after surgery. The clinical outcomes and quality of life (QOL) of CPPG were evaluated.

Dec 29, 2021

Carotid Artery Stenosis 12 Years after Cervical Radiotherapy

Background: Neurological complications after Radiotherapy of Nasopharyngeal Carcinoma (NPC) are frequent. The most frequent physiopathological effect is the structural change of the vasculature. According to the specific topography of irradiation and the dose, the artery can suffer from this treatment. This study aims to describe an uncommon acute neurovascular complication after Radiotherapy of nasopharyngeal carcinoma. However, it is difficult most of the time to establish a correlation betwe...

Dec 29, 2021

PICC Line Malposition Complicated by Patient Delirium, COVID-19 Infection, and Limited Vascular Support at a Smaller Facility

A 94-year-old male was admitted to the hospital with a UTI and found to be COVID-19 positive. Due to patient delirium and difficult venous access, a PICC line was placed for antibiotics and lab draws. The PICC line was subsequently found to be coiled in the left axillary vein. It was still functional and able to be used. The patient’s hospitalization was significantly complicated by COVID-19 and patient agitation. Additionally, the patient was located at a smaller facility without a vascular su...

  • Volume: 2, Issue: 5

Dec 29, 2021

Enhanced Recovery after Surgery and Regional Anesthesia for the Morbidly Obese

The rising rate of the morbidly obese population has created a need for intraoperative anesthetic management to be adjusted according to anatomic and physiological changes. In this case study, the goal is to explore and detail the beneficial effects of utilizing a combination of regional anesthesia and Enhanced Recovery After Anesthesia (ERAS) techniques to improve outcomes and decrease anesthesia-related morbidity and mortality.

Dec 28, 2021

Endoscopic Reduction of Acute Gastric Volvulus in a Four-Year-Old Girl with Beckwith-Wiedemann Syndrome

Endoscopic reduction in pediatric cases of acute Gastric Volvulus (GV) is rarely reported, especially cases of GV associated with Beckwith-Wiedemann Syndrome (BWS), which is a condition with congenital malformation. A 4-year-old girl with BWS presented to the emergency room with a complaint of abdominal pain while eating lunch. Physical examination revealed abdominal distension and severe tenderness but no peritoneal signs. A chest x-ray taken three months ago when she presented to the emergenc...

Dec 15, 2021

Culturally Sensitive Application of the Motivational Interview to Facilitate Care for a Black Male Presenting to the Emergency Department with Suicidal Ideation

Mental health presentations and Black male patients are independent features predictive of a difficult clinical encounter. The Motivational Interview (MI) technique was used to facilitate compliant psychiatric care for a Black male presenting to the Emergency Department (ED) with Suicidal Ideation (SI). The MI technique established a therapeutic alliance for shared decision-making. This case report reviews the four core MI skills by highlighting its culturally sensitive application for motivati...

Dec 14, 2021

Mucinous Ovarian Malignancy in a Young Woman: A Case Report

A 28-year-old woman underwent fertility-sparing surgery with a right salpingo-oophorectomy for a Stage IA well-differentiated mucinous cystadenocarcinoma. She remains disease-free at twenty months of follow-up. A literature review suggests that among young women with early-stage epithelial ovarian cancer, conservative, fertility-preserving surgery is safe. In a well-staged patient, neither ovarian preservation nor uterine conservation had an adverse impact on survival. Advanced stage, grade, an...

Dec 14, 2021

Clinical Value of Bioimpedance during Long-Term Cancer Therapy

This case report describes the use of bioimpedance spectroscopy (BIS) to monitor changes in hydration status and cellular function in a 73-year-old male patient with non-small cell lung cancer (NSCLC) undergoing a 12-week immunotherapy course. The parameters monitored were phase angle (PA), impedance ratio (IR), and cell membrane capacitance (Cm).

  • Volume: 2, Issue: 4

Dec 10, 2021

Melanoma Metastases versus Neurocysticercosis; the Importance of Correct Interpretation of MR Findings

Magnetic Resonance Imaging (MRI) is very useful for diagnosing brain melanoma (or its metastasis); however, its diagnosis is sometimes challenging. We present a case of a 65-year-old woman admitted to the hospital with an epileptic seizure. Brain MRI revealed multiple lesions, suggestive of chronic granulomas, possibly of parasitic origin, such as neurocysticercosis. The patient then underwent numerous examinations, which did not coincide with neurocysticercosis. Brain biopsy confirmed a melano...

Nov 24, 2021

Emergency Department Trauma Informed Care for a Black Male Gunshot Victim

Emergency Department (ED) based Trauma-Informed Care (TIC) was applied on a black male gunshot victim. The operational structure of University Medical Center New Orleans (UMCNO) ED has established an optimal interdisciplinary TIC foundation that addresses the health crisis of gun violence by accounting for its epidemiology. This foundation reinforces bedside emergency physician TIC with an ED-based Hospital Violence Intervention Program (HVIP) for TIC continuity. The approach mitigated the re-t...

Nov 15, 2021

Chronic Abdominal Pain due to the Unrecognized Stricturing Crohn’s Disease: A Case Report

This case report illustrates a stricturing Crohn’s disease insidiously progressing over several months into the intestinal obstruction. Extensive out-patient examination by Computed Tomography (CT), CT angiography, endoscopy, and plain nuclear Magnetic Resonance Imaging (MRI) showed no obvious pathology until complications manifested as an ileus. Abdominal pain without obvious pathology should be investigated further with advanced imaging methods rather than establishing a diagnosis of function...

Oct 25, 2021

Incompliant and Aggressive Behavior in a 2-Year-Old with Language Barrier During Oncological Treatment: How Can We Proceed with Necessary Therapy?

Aggressive and avoidant behavior are risk factors for disruption of necessary medical therapy and challenge for medical staff. This case report offers a classification of stress reactions in very young children during oncological medical treatment. Moreover, it illustrates a best-practice case of interdisciplinary treatment to explain medical procedures and improve the compliance of young children with chronic illnesses and language barriers.

  • Volume: 2, Issue: 3

Sep 03, 2021

Optimizing Medications in Patients with Cardiovascular Disease: A Case Report on Unrecognized Prescribing Cascades in Older Adults

Objective: Older adults with cardiovascular diseases are especially prone to polypharmacy due to comorbidities and consequent complexity of medication regimens. Prescribing cascades can occur when a side effect is misinterpreted as a new medical condition. Although the act of deprescribing is an integral part of good prescribing practice, it can be difficult to initiate without surveillance, appropriate communication, and primary care physician advocacy.

Aug 31, 2021

Migratory Polyarthralgia as Presenting Symptom of Occult Neoplasm

Malignancy presenting as polyarthralgia is rare, and correct diagnosis requires complete history, physical examination, imaging, and laboratory workup. We report a case of a 64-year-old male with abrupt severe debilitating migratory polyarthralgia as the initial presenting symptom of invasive ductal carcinoma. His joint pain was refractory to traditional analgesic medications, and his polyarthralgia resolved after surgical excision of his malignancy.

Aug 31, 2021

Multiple Splenic Infarcts Occurring as a Rare Complication of Babesiosis in an Elderly Patient on Anticoagulation

Babesiosis is a tick-borne disease parasitic protozoan infection characterized by the invasion of red blood cells leading to hemolytic anemia. Splenic infarction is a rare but severe manifestation of Babesiosis, which can be life-threatening. We present a case of an 86-year-old man that presented with generalized weakness, fever, chills, dark urine, and altered mental status. However, the patient had been on chronic anticoagulation with warfarin and had a supratherapeutic International Normaliz...

Aug 13, 2021

Optical Coherence Tomography Imaging of Anterior Descending Artery Thrombosis in a Young Bodybuilder

A 49-year-old healthy man with a history of exogenous anabolic steroid use presented with acute anterolateral ST-elevation myocardial infarction (STEMI). Coronary angiography revealed an 80% thrombotic occlusion of the proximal left anterior descending artery (LAD) without angiographic disease in other coronary arteries. Optical Coherence Tomography (OCT) imaging of the LAD, performed after improved flow with aspiration thrombectomy, revealed residual red thrombus. Following repeat aspiration t...

Aug 11, 2021

Pericardial Effusion in an Eight-Year-Old with Chronic Renal Disease

Pericardial effusions are not unusual in Chronic Kidney Disease (CKD). They can be related to renal disorder or have different etiologies, which must be investigated in each patient. We report an 8-year-old with CKD and asymptomatic pericardial effusion and discuss the diagnostic considerations and investigative paradigm. After an extensive investigation, we concluded that our patient represents the first pediatric case of Minoxidil-associated pericardial effusion.

  • Volume: 2, Issue: 2

Jul 14, 2021

Role of Whole Exome Sequencing in Diagnosis of Fetal Akinesia Deformation Sequence with Hydrops

The etiology of perinatal death often remains unidentified, yet proper diagnosis is crucial for appropriate family counseling and future pregnancy planning. We present a neonate delivered at 30 weeks and four days gestational age in the setting of hydrops fetalis and intrauterine growth restriction to non-consanguineous parents. Gross morphology was consistent with Fetal Akinesia Deformation Sequence (FADS) in addition to the hydropic changes.

Jul 08, 2021

Unexplained Death in Community Diagnosed at Post-Mortem as Covid Pneumonia

Covid infection is known to have a low fatality rate in young people and those without comorbidities. The classic triad of high temperature, new continuous cough, and loss of smell may not be present in all cases. Unusual presentations and initial negative Covid test can be detrimental in accessing treatment, leading to dangerous consequences in young people.

Jul 02, 2021

Ablation a Rare Ventricular Tachycardia Related to Pacemaker Electrode Position

A 65-year-old man with a VVI pacemaker and persistent Ventricular Tachycardia (VT) was referred to catheter ablation. The successful ablation site was 5 mm under the left pulmonary cuspid valve and 2 mm from the Right Ventricular (RV) electrode. No significant change on pacing thresholds, perception thresholds, and pacing impedance of pacemaker electrode before and after VT ablation.

Jun 28, 2021

Orbital Granulocytic Sarcoma Presenting Simultaneously with Acute Megakaryoblastic Leukemia

Orbital granulocytic sarcoma involving the central nervous system and coinciding with acute megakaryoblastic leukemia is a rare complication of this disease. We report a case of a previously healthy male infant 20-month-old who developed acute megakaryoblastic leukemia and in whom the initial diagnosis was difficult because of associated severe myelofibrosis. We focus on this report on the clinical and cyto-histological features and problems concerning differential diagnosis and the importance ...

  • Volume: 2, Issue: 1

Apr 13, 2021

Delayed Closed Reduction and Cast Immobilization for Ring and Little Fingers Carpometacarpal Joints Dislocations of the Right Hand - Success Can Still Happen: A Case Report

A young gentleman aged 22-year-old was referred to the trauma and Orthopaedics department with post-traumatic swelling and pain in his right hand for -one week- duration. The mechanism of trauma was due to uncouth crush injury. The underlying lesion was a dorsal dislocation of the carpometacarpal (CMC) joints of the right ring and little fingers. Despite being lately presented to us due to a delay in the diagnosis, a closed reduction trial under local anesthetic infiltration was performed. The ...

Feb 24, 2021

The Relevance of the European Charter of Patients’ Rights as a Tool for Advocacy in the Framework of the Covid-19 Pandemic

In 2002, Active Citizenship Network (ACN), together with 12 citizen organizations from 15 different EU countries, established the European Charter of Patients’ Rights, which lists fourteen fundamental patients’ rights which each EU country must protect and guarantee. The fourteen rights apply to all individuals and, together, aim to guarantee a “high level of human health protection”, as claimed in Article 35 of the Charter of Fundamental Rights of the European Union, and to assure the high qua...

Feb 09, 2021

A Case of Protracted Resuscitation and Fibrinolysis During Cardiac Arrest in Emergency Room Due to St-Elevation Myocardial Infarction

Background: Different therapies have been studied in patients with cardiac arrest due to ST-Elevation Myocardial Infarction (STEMI). However, none of the anti-arrhythmic or vasopressor medications have consistently been shown to improve these patients’ survival or neurological outcomes. Recent studies show that administration of fibrinolytic drugs during cardiac arrest may improve survival outcomes and neurological status.

Jan 28, 2021

Integrating a Novel Medication Risk Score and Use of an Advanced Clinical Decision Support System into a Pharmacist- and Nurse-Coordinated Transition of Care Program to Mitigate Drug Interactions

Purpose: Patients affected by polypharmacy are at higher risk for significant multi-drug interactions. Inadequate management of these multi-drug interactions in patients discharged from the hospital can lead to readmission and/or medication-related morbidity.

Jan 15, 2021

A Case of Short Stature and Sagittal Craniosynostosis in an Omani Girl with Hereditary Hypophosphatemic Rickets with Hypercalciuria

Hereditary Hypophosphatemic Rickets with Hypercalciuria (HHRH) is a rare autosomal recessive form of hypophosphatemic rickets. It is caused by mutations in the SLC34A3 gene, which encodes the renal sodium-dependent phosphate cotransporter 2c (NaPi-IIc). It is characterized by normal plasma levels of calcium and 25-hydroxyvitamin D, an elevated level of 1,25-Dihydroxyvitamin D [1,25(OH)2D], a low level of parathyroid hormone, hypophosphatemia, hyperphosphaturia, hypercalciuria, and a low level o...

  • Volume: 1, Issue: 7

Dec 15, 2020

Results of Bronchial Artery Embolization for Massive Hemoptysis

Background: Hemoptysis is caused by several lung diseases and can be fatal in some cases. However, the risk factors of hemoptysis and prognosis remain unclear. Methods: We present the cases of 15 patients with hemoptysis who had undergone Bronchial Arterial Embolization (BAE) at our hospital. We also analyze the patient’s background, hemoptysis risk, and prognosis.

Dec 03, 2020

Takotsubo or not Takotsubo Syndrome: A Case Report

Background: Takostubo cardiomyopathy is defined by the presence of transient wall motion abnormalities, most of the time in the form of an apical ballooning and without coronary occlusion. Causes remain unclear. Psychological or physical stress could cause this pathology related to catecholamine cardiotoxicity. The distinction between Takotsubo cardiomyopathy and myocardial infarction is not always easy to make. This particular clinical case is a good illustration of that situation.

Nov 26, 2020

The On-Call Burden of Physicians: Discussion, Recommendations and Risk Mitigation Strategies

Dr. William Stewart, surgeon and chief of staff of Johns Hopkins Medical School in the 1880s, devised a grueling and prolonged training program for his residents in which they basically lived at the hospital and worked extremely long days with very little sleep or rest. In this manner, he believed physicians would truly be trained to the maximum extent that they could. This training regimen caught on and became the prevailing training method of residency programs throughout the US.

Nov 25, 2020

Allergic Bronchopulmonary Aspergillosis: An Under-recognized Disease in Croatia

Allergic Bronchopulmonary Aspergillosis (ABPA) is an uncommon, frequently unrecognized or misdiagnosed pulmonary disease, which occurs predominantly in patients with asthma or cystic fibrosis. It is estimated that ABPA affects more than 4.8 million asthmatic patients worldwide. In Croatia, the prevalence of aspergillosis is unknown, and very sparse clinical reports have been published, mainly on the invasive form of the disease. However, some ecological and animal studies pointed to the possibi...

Nov 12, 2020

Use of Carotid Artery Compressibility Detected on Ultrasonography During Chest Compression to Validate Return of Spontaneous Circulation

Background: The current Cardiopulmonary Resuscitation (CPR) guidelines recommend a cardiac rhythm check every 2 min to evaluate the Return of Spontaneous Circulation (ROSC). Central artery pulse checks are generally performed manually when an organizing rhythm is recognized on the monitor, but several studies have shown that this method is not reliable. Recently, a case series of a novel approach can be used to determine the presence or absence of pulses using direct Point-of-Care Ultrasound (P...

  • Volume: 1, Issue: 6

Nov 10, 2020

Opioid Response in an Individual with Altered Cytochrome P450 2D6 Activity: Implications of a Pharmacogenomics Case

The benefits of opioid use in older adults to manage chronic non-cancer pain must outweigh the risks as these individuals are more susceptible to the side effects and drug interactions associated with opioids. Pharmacogenomic testing supports clinicians in selecting appropriate opioid therapy while minimizing these risks.

Oct 10, 2020

Mutation Pattern Analysis of the Public SARS-Cov-2 Genome Sequences

COVID-19 called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is an ongoing outbreak that has caused a crucial global public health issue over many countries. The incidence rate is significantly increased in the entire world, including Korea. In this study, we conducted an in-depth analysis of mutations using 126 sequences available in public. In total, 177 mutation sites were detected using multiple sequences alignment. We observed that the only 30 mutations were shared with mor...

Sep 10, 2020

Brain Metastasis from Pancreatic Adenocarcinoma in a Patient with Previous Good Response to Chemotherapy - a Case Report

Pancreatic adenocarcinoma usually metastasizes to the liver, lungs, lymph nodes, or bones. However, brain metastases have also been shown in some rare documented cases and usually predict a very poor prognosis. We present the case of a 56-year-old male who was diagnosed in June of 2017 with primary metastasized pancreatic adenocarcinoma and, after a good initial response to palliative chemotherapy started to complain about headaches and altered visual acuity, with evidence of a left occipital i...

Sep 08, 2020

Traumatic Vertebral Fracture with Coexisting Enchondroma: a Case-Report and Review of the Literature

Enchondroma of the vertebral spine is a rare clinical entity. For symptomatic enchondroma, surgical resection is the treatment of choice. Here we present the atypical case of a patient with non-symptomatic spinal enchondroma (D9), discovered because of a dorsal trauma that led to a D9 fracture. The pre-operative diagnostic workup gave a suspicion of a co-existing neoplastic lesion, leading to the consideration of a more likely pathologic fracture than a traumatic lesion, with no segmental insta...

  • Volume: 1, Issue: 5

Sep 07, 2020

Endomorphin-2 Derivatives: Rapid Relief of Various Pains by Topical Administration or by Superficial Local Injection

Background and purpose: Endomorphin-2 is a physiologic tetrapeptide amide, Tyr-Pro-Phe-Phe-NH2, which has been shown to provide an analgesic effect in mice and rats by injection into the brain. In our previous report, we showed that certain Endomorphin-2 derivatives, such as N-Ac-Tyr-Pro-Phe-Phe-NH2 could provide instant analgesia on topical application. The case reports presented herein reveal that a number of N-substituent radicals enhance analgesic effects of the derivative applied topically...

Aug 17, 2020

Sulcal Artery Syndrome as Atypical Ischemic Complication after Anterior Cervical Discectomy and Fusion: a Case Report

Anterior Cervical Discectomy and Fusion (ACDF) are frequent interventions. Neurologic worsening and Horner syndrome are known as very rare complications, but none described a Brown-Sequard syndrome as clinical feature of a sulcal artery syndrome. We report a case of a 47-year-old woman who underwent a double level ACDF with plating (C3–C5) and who developed 7–10 hours after the surgery a progressive anesthesia on the right side, with a level on D3, associated with impairment in discriminating h...

Jul 27, 2020

Hard-to-Diagnose Unilateral Facial Dermatosis

Demodicosis is a common parasitic infection of the pilosebaceous unit caused by Demodex mites. This is the case of facial demodicosis of atypical presentation that appears as a unilateral erythemato-squamous plaque, whose initial possible diagnosis was seborrheic dermatitis and seborrheic pemphigus. The skin biopsy revealed an increased number of Demodex organisms in the pilosebaceous unit. Our patient was treated with topical metronidazole, topical tacrolimus, and oral ivermectin, and showed n...

Jul 27, 2020

Similarities and Differences among Genetic Prionopathies: Comparative Description of Familial Creutzfeldt-Jakob Disease and Familial Fatal Insomnia

Human prionopathies can be sporadic, hereditary, or acquired disorders. Familial Creutzfeldt-Jakob (F-CJD), Familial Fatal Insomnia (FFI), and Gerstmann-Sträussler-Scheinker (GSS) are the main hereditary variants. We describe the first FFI case in Galicia and other F-CJD, underlying their similitudes and differences.

  • Volume: 1, Issue: 4

Jul 25, 2020

The Case Report of HBoV Acute Gastroenteritis in a Two-Month- Old Infant

Introduction: The Human bocavirus was identified from the nasopharyngeal aspirate specimen in 2005, that it includes four subtypes (HBoV 1–4). The HBoV-1 is a major subtype in children’s acute respiratory infections, and others (HBoV 2–4) were in stool specimens. The pathogenic role of Human bocavirus 2–4 in acute Gastroenteritis has not confirmed yet, and therefore all of the reports were done to confirmation of this issue.

Jul 24, 2020

Burkholderia Cepacia Sepsis: A Neonatal Case

Burkholderia cepacia is an aerobic, glucose non-fermenting, motile, and multidrug-resistant gram-negative bacteria, which is not considered from the normal human flora. It is a rare cause of sepsis in newborns, and its transmission involves human contact with heavily contaminated medical devices and disinfectants.

Jul 22, 2020

Do We Need to Increase Factor VIII to Target Level before Surgical Intervention?

Hemophilia A is a bleeding disorder characterized by a decreased level of factor VIII inherited by the X chromosome. Preoperative and postoperative planning is crucial in the presence of fractures requiring surgical treatment in hemophilia patients. A 16-year-old adolescent hemophilia A patient with a trivial fall on his left elbow applied to the emergency room, and a Mayo type 2A olecranon fracture was detected. 40 IU/kg Factor VIII replacement was performed since the preoperative level was 8%...

Jul 20, 2020

Pertussis Associated with Viral Infections in Infants

Although pertussis alone is a disease that usually has a benign course and a favorable outcome, we must keep in mind that children can have a respiratory viral coinfection associated with a pertussis infection. Mixed respiratory tract infections may be responsible for more severe disease. The rapid microbiological analysis contributes to their adequate diagnosis and timely treatment.

Jul 08, 2020

Analysis of the Four Heart Sounds Statistical Study and Spectro- Temporal Characteristics

The study of the functioning of the heart is significant for the diagnosis of different cardiac pathologies. The Phonocardiogram Signal (PCG) is the signal generated after converting the sound noises coming from the heart into an electrical signal, it groups together a set of four cardiac noises (S1, S2, S3 and S4) which are in direct correlation with cardiac activity. The Short-Term Fourier Transform (STFT) is an analytical technique that describes the evolution of the time and frequency behav...

  • Volume: 1, Issue: 3

Jul 03, 2020

Transcranial Photobiomodulation for Fibromyalgia

Fibromyalgia (FM) is a chronic syndrome characterized by widespread musculoskeletal pain, fatigue, stiffness, and associated features such as insomnia, mood and anxiety symptoms and cognitive dysfunction. In the general population, FM is prevalent with a rate of 2%–4% -mainly women- and causes functional impairment and disability [1]. Most patients with FM require a combination of medications and other interventions [2,3]; yet a partial response is common. FM supposedly results from the enhance...

Jun 23, 2020

Massive Residual Cyst Involving Mandibular Edentulous Jaw- A Misleading Entity and the Treatment Challenges: A Case Report

Residual inflammatory odontogenic cysts are formed at the region of the previous extraction of the tooth. It can also form due to incomplete removal of other common odontogenic cysts of the jaw. A residual cyst occurs commonly in the maxilla than mandible and shows more of male predilection. Usually, residual cysts are asymptomatic, and the patient normally seeks treatment once it gets infected or causes any other discomfort. It can sometimes diagnose as an incidental finding in radiographs.

Jun 19, 2020

General Pathology Markers, Genome Drugs and Effective Therapy

The concept of general pathology is cornerstone for the theoretical medicine. In addition to the General Human Pathology we have managed to discover General Pathology Markers (GPM), which are sensitive to all types of diseases. Using GMP enables us to find a strict quantitative boundary between organism’s normal and pathological conditions.

Jun 19, 2020

The Dermoid Cyst of the Auricle

Dermoidcysts of the auricle are extremely rare. A 13-year-old female patient was admitted to our clinic with the complaint of a painful, slowly growing mass that had been present behind her right ear since birth. Ear examination revealed a soft, approximately 2 cm x 2 cm cystic mass on the posterior aspect of the right auricle. Histopathological examination of the excised mass was reported as dermoid cyst. The patient, who had no problem after the operation, was called to the controls and disch...

May 13, 2020

An Illustrative Case of Phenoconversion due to Multi-Drug Interactions

The study of pharmacogenetics aids in the identification of variable therapeutic responses, identification of adverse reactions to drugs, and supports development and discovery. While advances in pharmacogenetic testing have been significant in recent years, The U.S. Food and Drug Administration (FDA) cautions against using this information solely as the basis to alter therapeutic treatments.In the case presented below, a patient with lung cancer was prescribed the standard dose of codeine for ...

  • Volume: 1, Issue: 2

Apr 27, 2020

Vitamin D Repletion Plus Sitagliptin is Associated with Increases in Serum C-Peptide and Decreases in Gad-65 and Islet Cell Antibodies and Hemoglobin A1c in a Patient with Latent Autoimmune Diabetes of Adults (LADA)

LADA is characterized by adult-onset and circulating autoantibodies e.g., glutamic acid decarboxylase (GAD-65). LADA may be misdiagnosed, as it has features of both Type 1 and Type 2 diabetes. Dipeptidyl Peptidase-4 (DPP-4) (CD26) is a transmembrane glycoprotein immunomodulator causing a Th1/Th17 dominant milieu while suppressing anti-autoimmune Th2/Treg expression. Th1 and Th17 secrete pro-inflammatory cytokines that mediate ß cell autoreactivity. DPP-4 inhibitors (DPP4I), e.g., sitagliptin (S...

Apr 20, 2020

Role of Adjuvant Steroid Therapy to Limit Radiation Pneumonitis in Stereotactic Body Radiation Therapy (SBRT) Treated Lung Cancer

Background: The median age of lung cancer diagnosis is 70 years with patients often precluded as surgical candidates due to comorbidities, tumor location, and refusal of surgery. In these cases, stereotactic body radiation therapy (SBRT) has become the treatment of choice. With SBRT, there remains a risk of radiation pneumonitis (RP) and other toxicities. Adjuvant corticosteroids could be a tool to diminish radiation toxicity. However, little data exists exploring this treatment.

Apr 13, 2020

Apoplexy of an Adrenocorticotrophic Pituitary Macro Adenoma After Treatment of 1 Acute Myocardial Infarction

Background: Cushing's disease is associated with high vascular morbidity and mortality. A pituitary adenoma apoplexy is a rare but a potentially life-threatening clinical syndrome, occurring as a result of hemorrhage or infarction in a pituitary adenoma. An important risk factor for a PA is the administration of anticoagulants. Patients with Cushing’s disease have prothrombotic changes and impairment in fibrinolysis resulting in increased risk of thromboembolism. Also an increased activation of...

Apr 07, 2020

Terlipressin as Salvage Therapy in Mixed Polypharmacy Overdose with Refractory Circulatory Shock and Pathological Diuresis

Presentations of mixed polypharmacy overdose are increasingly common and frequently require treatment within the Intensive Care Unit (ICU). We present the novel use of Terlipressin acetate to rapidly overcome refractory shock in a patient that presented with mixed polypharmacy overdose. The Shock was refractory to conventional vasopressors and use of terlipressin acetate reduced length of stay in the ICU.

Apr 01, 2020

5 Case Reports Intoxication from Smoking "Spice"

"Spice" synthetic cannabinols, and as new psychoactive drugs. Studies have shown that many spice products are sprayed with synthetic cannabinoids, substances that cause intoxication. Despite widespread use in Europe, spice products were introduced to the United States only recently. In the world literature data on the Spice intoxication clinic is not enough. To provide preliminary management experience for future cases, we describe 5 patients with Intoxication from smoking “Spice” after who con...

  • Volume: 1, Issue: 1

Mar 25, 2020

Evaluation on Quality of Life in Patients with Low Back Pain Preoperatively and After Undergoing Cryoablation of the Facet Joints

Goal of the research: Although studies show good results on relief of Low Back Pain (LBP) after cryoablation of the facet joints, we wished to evaluate the changes in patient’s quality of life. This included factors such as their participation in daily activities, social life, work performance, mental health and overall self esteem.

Mar 19, 2020

A Case of Pulmonary Arterial Hypertension Secondary to Hepatitis C Treatment with Ledipasvir/Sofosbuvir Combination

The new Direct Acting Antivirals (DAA) have revolutionised the treatment of hepatitis C virus (HCV), replacing interferon (IFN) regimes which are known to cause adverse events with lower success rates. However, as these are relatively new drugs, all adverse events in the heterogeneous population outside of a clinical trial environment have yet to be determined. We report a case of newly diagnosed Pulmonary Hypertension (PHTN), where completion of treatment with Sofosbuvir (trade name Harvoni©) ...

Mar 10, 2020

Reverse Shoulder Arthroplasty for Humeral Head and Glenoid Osteonecrosis

A 62-year-old male patient presented with pain accompanied by lack of motion in his right shoulder joint. The MRI finding was humeral head and glenoid osteonecrosis of the right shoulder. Although rare, osteonecrosis of the humeral head is sometimes accompanied by simultaneous osteonecrosis of the glenoid cavity thus blocking the motion in the shoulder. Reversed shoulder arthroplasty is the best option for restoration of the pain free mobility of the joint.

Mar 06, 2020

Fitzsimmons-Walson-Mellor Syndrome

Fitzsimmons-Walson-Mellor (F-W-M) syndrome is a rare disease characterized by progressive kidney failure, sensorineural deafness, and variable spastic paraparesis. We report the case of a 30-year-old male who had been diagnosed with non-progressive connatal encephalopathy, spastic tetraparesis of paraplegic predominance, and intellectual retardation at the age of 14 months. During adolescence, he developed proteinuria, with the subsequent detection of hypertension and elevated plasma creatinine...

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