Heldner Mirjam Rachel received her doctorate in medicine
and habilitation in clinical neurology from the University of Bern, Switzerland and is currently working there as a consultant at the Stroke Center. She got her Master in Science in European Stroke Medicine from the Danube University, Austria and completed a fellowship in clinical stroke research at the University of Oxford, UK.
Heldner Mirjam's primary clinical and research goals and interests are directed towards large arterial vessel occlusion, stroke scales, stroke aetiology, vascular diseases as such, intracranial stenosis, stroke prevention and (endovascular) treatment, spinal cord ischemia and manual dexterity in multiple sclerosis.
- Rajeev K Verma, Johannes Slotboom, Cäcilia Locher, Mirjam R Heldner, Christian Weisstanner, Eugenio Abela, Frauke Kellner-Weldon, Martin Zbinden, Christian P Kamm, Roland Wiest (2016) Characterization of Enhancing MS Lesions by Dynamic Texture Parameter Analysis of Dynamic Susceptibility Perfusion Imaging. BioMed research international 2016: a01.
- Peter Vanacker, Mirjam R Heldner, Michael Amiguet, Mohamed Faouzi, Patrick Cras, George Ntaios, Marcel Arnold, Heinrich P Mattle, Jan Gralla, Urs Fischer, Patrik Michel (2016) Prediction of Large Vessel Occlusions in Acute Stroke: National Institute of Health Stroke Scale Is Hard to Beat. Critical care medicine 44: 6. e336-e343 Jun.
- Susanna M Zuurbier, Marcel Arnold, Saskia Middeldorp, Anne Broeg-Morvay, Suzanne M Silvis, Mirjam R Heldner, Julia Meisterernst, Banne Nemeth, Eva R Meulendijks, Jan Stam, Suzanne C Cannegieter, Jonathan M Coutinho (2016) Risk of Cerebral Venous Thrombosis in Obese Women. JAMA neurology 73: 5. 579-584 May.
- Mirjam R Heldner, Kety Hsieh, Anne Broeg-Morvay, Pasquale Mordasini, Monika Bühlmann, Simon Jung, Marcel Arnold, Heinrich P Mattle, Jan Gralla, Urs Fischer (2016) Clinical prediction of large vessel occlusion in anterior circulation stroke: mission impossible? Journal of neurology 263: 8.1633-1640 Aug.
- Timo Kahles, Marie-Luise Mono, Mirjam Rachel Heldner, Ralf Werner Baumgartner, Hakan Sarikaya, Andreas Luft, Stephan Bohlhalter, Christopher Traenka, Stefan T Engelter, Natalia Kurka, Martin Köhrmann, Sami Curtze, Patrik Michel, Turgut Tatlisumak, Krassen Nedeltchev (2016) Repeated Intravenous Thrombolysis for Early Recurrent Stroke: Challenging the Exclusion Criterion. Stroke; a journal of cerebral circulation 47: 8. 2133-2135 Aug.
- Mirjam R Heldner, Heinrich P Mattle, Urs Fischer (2016) Letter by Heldner et al Regarding Article, "Prehospital Acute Stroke Severity Scale to Predict Large Artery Occlusion: Design and Comparison With Other Scales". Stroke; a journal of cerebral circulation 47: 9. Sep.
- Mirjam R Heldner, Marwan El-Koussy, Marcel Arnold, Simon Jung (2016) Wrong side oculomotor nerve palsy. British journal of hospital medicine (London, England : 2005) 77: 8. 488-489 Aug.
- Mirjam R Heldner, Simon Jung, Christoph Zubler, Pasquale Mordasini, Anja Weck, Marie-Luise Mono, Christoph Ozdoba, Marwan El-Koussy, Heinrich P Mattle, Gerhard Schroth, Jan Gralla, Marcel Arnold, Urs Fischer (2015) Outcome of patients with occlusions of the internal carotid artery or the main stem of the middle cerebral artery with NIHSS score of less than 5: comparison between thrombolysed and non-thrombolysed patients. Journal of neurology, neurosurgery, and psychiatry 86: 7. 755-760 Jul.
- Peter Vanacker, Mirjam R Heldner, David Seiffge, Hubertus Mueller, Ashraf Eskandari, Christopher Traenka, George Ntaios, Pascal J Mosimann, Roman Sztajzel, Vitor Mendes Pereira, Patrick Cras, Stefan Engelter, Philippe Lyrer, Urs Fischer, Dimitris Lambrou, Marcel Arnold, Patrik Michel (2015) ASTRAL-R score predicts non-recanalisation after intravenous thrombolysis in acute ischaemic stroke. Thrombosis and haemostasis 113: 5. 1121-1126 May.
- Christian P Kamm, Heinrich P Mattle, René M Müri, Mirjam R Heldner, Verena Blatter, Sandrine Bartlome, Judith Lüthy, Debora Imboden, Giovanna Pedrazzini, Stephan Bohlhalter, Roger Hilfiker, Tim Vanbellingen (2015) Home-based training to improve manual dexterity in patients with multiple sclerosis: A randomized controlled trial. Multiple sclerosis (Houndmills, Basingstoke, England) 21: 12. 1546-1556 Oct.
- Chiara Zecca, Mirjam R Heldner, Christian P Kamm, Gianna C Riccitelli, Giulio Disanto, Matteo Caporro, Alessandro Cianfoni, Emanuele Pravatà, Claudio Gobbi (2015) Natalizumab in spinal multiple sclerosis in a daily clinical setting. Expert opinion on biological therapy 15: 5. 633-640 May.
- Mirjam R Heldner, Mila Nedelcheva, Xin Yan, Johannes Slotboom, Etienne Mathier, Justine Hulliger, Rajeev K Verma, Matthias Sturzenegger, Simon Jung, Corrado Bernasconi, Marcel Arnold, Roland Wiest, Urs Fischer (2015) Dynamic changes of intramural hematoma in patients with acute spontaneous internal carotid artery dissection. International journal of stroke : official journal of the International Stroke Society 10: 6. 887-892 Aug.
- Marc D Gilgen, Dariusz Klimek, Kai T Liesirova, Julia Meisterernst, Pascal P Klinger-Gratz, Gerhard Schroth, Pasquale Mordasini, Kety Hsieh, Johannes Slotboom, Mirjam R Heldner, Anne Broeg-Morvay, Marie-Luise Mono, Urs Fischer, Heinrich P Mattle, Marcel Arnold, Jan Gralla, Marwan El-Koussy, Simon Jung (2015) Younger Stroke Patients With Large Pretreatment Diffusion-Weighted Imaging Lesions May Benefit From Endovascular Treatment. Stroke; a journal of cerebral circulation 46: 9. 2510-2516 Sep.
- Pascal P Klinger-Gratz, Gerhard Schroth, Jan Gralla, Simon Jung, Christian Weisstanner, Rajeev K Verma, Pasquale Mordasini, Frauke Kellner-Weldon, Kety Hsieh, Mirjam R Heldner, Urs Fischer, Marcel Arnold, Heinrich P Mattle, Marwan El-Koussy (2015) Protected stent retriever thrombectomy prevents iatrogenic emboli in new vascular territories. Neuroradiology 57: 10. 1045-1054 Oct.
- Marcel Arnold, Agnieszka Slezak, Marwan El-Koussy, Rudolf Lüdi, Oliver Findling, Marie-Luise Mono, Mirjam Rachel Heldner, Urs Fischer, Pasquale Mordasini, Gerhard Schroth, Heinrich P Mattle, Jan Gralla, Simon Jung (2015) Occlusion Location of Middle Cerebral Artery Stroke and Outcome after Endovascular Treatment. European neurology 74: 5-6. 315-321 12.
- J P Mohr, Michael K Parides, Christian Stapf, Ellen Moquete, Claudia S Moy, Jessica R Overbey, Rustam Al-Shahi Salman, Eric Vicaut, William L Young, Emmanuel Houdart, Charlotte Cordonnier, Marco A Stefani, Andreas Hartmann, Rüdiger von Kummer, Alessandra Biondi, Joachim Berkefeld, Catharina J M Klijn, Kirsty Harkness, Richard Libman, Xavier Barreau, Alan J Moskowitz (2014) Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial. Lancet (London, England) 383: 9917. 614-621 Feb.
- Pascal P Gratz, Simon Jung, Gerhard Schroth, Jan Gralla, Pasquale Mordasini, Kety Hsieh, Mirjam R Heldner, Heinrich P Mattle, Marie-Luise Mono, Urs Fischer, Marcel Arnold, Christoph Zubler (2014) Outcome of standard and high-risk patients with acute anterior circulation stroke after stent retriever thrombectomy. Stroke; a journal of cerebral circulation 45: 1. 152-158 Jan.
- Pascal P Gratz, Marwan El-Koussy, Kety Hsieh, Sebastian von Arx, Marie-Luise Mono, Mirjam Rachel Heldner, Urs Fischer, Heinrich P Mattle, Christoph Zubler, Gerhard Schroth, Jan Gralla, Marcel Arnold, Simon Jung (2014) Preexisting cerebral microbleeds on susceptibility-weighted magnetic resonance imaging and post-thrombolysis bleeding risk in 392 patients. Stroke; a journal of cerebral circulation 45: 6. 1684-1688 Jun.
- Rudolf Luedi, Kety Hsieh, Agnieszka Slezak, Marwan El-Koussy, Urs Fischer, Mirjam R Heldner, Julia Meisterernst, Marie-Luise Mono, Christoph Zubler, Pasquale Mordasini, Christoph Ozdoba, Heinrich P Mattle, Gerhard Schroth, Jan Gralla, Marcel Arnold, Simon Jung (2014) Age dependency of safety and outcome of endovascular therapy for acute stroke. Journal of neurology 261: 8. 1622-1627 Aug.
- Mirjam R Heldner, Thomas Pilgrim, Kerstin Wustmann, Kety Hsieh, Heinrich P Mattle, Marcel Arnold, Simon Jung (2014) Acute carotid T occlusion in a young patient: cryptogenic origin? Stroke; a journal of cerebral circulation 45: 7. e125-e127 Jul.
- Mirjam R Heldner, Tim Vanbellingen, Stephan Bohlhalter, Heinrich P Mattle, René M Müri, Christian P Kamm (2014) Coin rotation task: a valid test for manual dexterity in multiple sclerosis. Physical therapy 94: 11. 1644-1651 Nov.
- M R Heldner, H P Mattle, S Jung, U Fischer, J Gralla, C Zubler, M El-Koussy, G Schroth, M Arnold, M - L Mono (2014) Thrombolysis in patients with prior stroke within the last 3 months. European journal of neurology 21: 12. 1493-1499 Dec.
- P Mordasini, C Brekenfeld, J V Byrne, U Fischer, M Arnold, M R Heldner, R Lüdi, H P Mattle, G Schroth, J Gralla (2013) Technical feasibility and application of mechanical thrombectomy with the Solitaire FR Revascularization Device in acute basilar artery occlusion. AJNR. American journal of neuroradiology 34: 1. 159-163 Jan.
- S Jung, J Gralla, U Fischer, M - L Mono, A Weck, R Lüdi, M R Heldner, O Findling, M El-Koussy, C Brekenfeld, G Schroth, H P Mattle, M Arnold (2013) Safety of endovascular treatment beyond the 6-h time window in 205 patients. European journal of neurology 20: 6. 865-871 Jun.
- U Fischer, M - L Mono, G Schroth, S Jung, P Mordasini, M El-Koussy, A Weck, C Brekenfeld, O Findling, A Galimanis, M R Heldner, M Arnold, H P Mattle, J Gralla (2013) Endovascular therapy in 201 patients with acute symptomatic occlusion of the internal carotid artery. European journal of neurology 20: 7. 1017-24, e87 Jul.
- Mirjam R Heldner, Christoph Zubler, Heinrich P Mattle, Gerhard Schroth, Anja Weck, Marie-Luise Mono, Jan Gralla, Simon Jung, Marwan El-Koussy, Rudolf Lüdi, Xin Yan, Marcel Arnold, Christoph Ozdoba, Pasquale Mordasini, Urs Fischer (2013) National Institutes of Health stroke scale score and vessel occlusion in 2152 patients with acute ischemic stroke. Stroke; a journal of cerebral circulation 44: 4. 1153-1157 Apr.
- Sanne M Zinkstok, Stefan T Engelter, Henrik Gensicke, Philippe A Lyrer, Peter A Ringleb, Ville Artto, Jukka Putaala, Elena Haapaniemi, Turgut Tatlisumak, Yaohua Chen, Didier Leys, Hakan Sarikaya, P Michel, Céline Odier, Jörg Berrouschot, Marcel Arnold, Mirjam R Heldner, Andrea Zini, Valentina Fioravanti, Visnja Padjen, Ljiljana Beslac-Bumbasirevic, Alessandro Pezzini, Yvo B Roos, Paul J Nederkoorn (2013) Safety of thrombolysis in stroke mimics: results from a multicenter cohort study. Stroke; a journal of cerebral circulation 44: 4. 1080-1084 Apr.
- Michelle von Babo, Gian Marco De Marchis, Hakan Sarikaya, Christian Stapf, Fréderique Buffon, Urs Fischer, Mirjam R Heldner, Jan Gralla, Simon Jung, Barbara Goeggel Simonetti, Heinrich P Mattle, Ralf W Baumgartner, Marie-Germaine Bousser, Marcel Arnold (2013) Differences and similarities between spontaneous dissections of the internal carotid artery and the vertebral artery. Stroke; a journal of cerebral circulation 44: 6. 1537-1542 Jun.
- Rajeev Kumar Verma, Johannes Slotboom, Mirjam Rachel Heldner, Mirjam Rahel Heldner, Frauke Kellner-Weldon, Raimund Kottke, Christoph Ozdoba, Christian Weisstanner, Christian Philipp Kamm, Roland Wiest (2013) Characterization of microcirculation in multiple sclerosis lesions by dynamic texture parameter analysis (DTPA). PloS one 8: 7. 07.
- Simon Jung, Marc Gilgen, Johannes Slotboom, Marwan El-Koussy, Christoph Zubler, Claus Kiefer, Rudolf Luedi, Marie-Luise Mono, Mirjam R Heldner, Anja Weck, Pasquale Mordasini, Gerhard Schroth, Heinrich P Mattle, Marcel Arnold, Jan Gralla, Urs Fischer (2013) Factors that determine penumbral tissue loss in acute ischaemic stroke. Brain : a journal of neurology 136: Pt 12. 3554-3560 Dec.
- Henrik Gensicke, Sanne M Zinkstok, Yvo B Roos, David J Seiffge, Peter Ringleb, Ville Artto, Jukka Putaala, Elena Haapaniemi, Didier Leys, Régis Bordet, Patrik Michel, Céline Odier, Jörg Berrouschot, Marcel Arnold, Mirjam R Heldner, Andrea Zini, Guido Bigliardi, Visnja Padjen, Nils Peters, Alessandro Pezzini, Christian Schindler, Hakan Sarikaya, Leo H Bonati, Turgut Tatlisumak, Philippe A Lyrer, Paul J Nederkoorn, Stefan T Engelter (2013) IV thrombolysis and renal function. Neurology 81: 20. 1780-1788 Nov.
- M Heldner, J Gralla, H Hungerbühler, U Fischer, M Arnold (2012) [Acute occlusions of cerebral arterial vessels - intravenous versus intraarterial thrombolysis]. Therapeutische Umschau. Revue the´rapeutique 69: 9. 511-516 Sep.
- M R Heldner, M Arnold, J Gralla, U Fischer (2012) [Management of transient ischemic attack (TIA) and acute stroke]. Praxis 101: 6. 389-397 Mar.
- Christian P Kamm, Mirjam R Heldner, Tim Vanbellingen, Heinrich P Mattle, René Müri, Stephan Bohlhalter (2012) Limb apraxia in multiple sclerosis: prevalence and impact on manual dexterity and activities of daily living. Archives of physical medicine and rehabilitation 93: 6. 1081-1085 Jun.
- Mirjam Rachel Heldner, Marcel Arnold, Krassen Nedeltchev, Jan Gralla, Jürgen Beck, Urs Fischer (2012) Vascular diseases of the spinal cord: a review. Current treatment options in neurology 14: 6. 509-520 Dec.
- Ute E K Wolf-Schnurrbusch, Nicole Röösli, Eva Weyermann, Mirjam R Heldner, Katja Höhne, Sebastian Wolf (2007) Ethnic differences in macular pigment density and distribution. Investigative ophthalmology & visual science 48: 8. 3783-3787 Aug.
- 2013: (First author) Award (outstanding junior research in stroke), European Stroke Organisation (ESO), project: Outcome in patients with low NIHSS score despite central vessel occlusion: single-center retrospective comparison of conservative treatment and thrombolysis.
- 2014: (Co-author) Investigator Award, European Stroke Organisation (ESO).
- 2014: (Co-author) Peter Huber Award 2015 (Co-author) Day of Clinical Research Award, University of Bern/CH.
- 2017: (Co-author) Day of Clinical Research Award, University of Bern/CH.
- 2018: (Co-author) Investigator Award, European Stroke Organisation (ESO).
- 2012/2013: Swiss Heart Foundation. Main applicant: HP Mattle. 1st joint applicant: MR Heldner, 2nd joint applicant: U Fischer. Validity of NIHSS score in predicting arterial occlusion in anterior and posterior circulation stroke.
- 2013/2014: Swiss Heart Foundation. 1st joint applicant: U Fischer, 2nd joint applicant: HP Mattle. Design of a new clinical score in predicting central arterial vessel occlusion in anterior and posterior circulation stroke.
- 2015-2018: Inselgrant. Stroke aetiology in Bern – To lower the burden of cryptogenic stroke.
- 2016-2018: SNF Advanced Postdoc Mobility Grant. Novartis Foundation for Medical-Biological Research. Grant. Stroke aetiology: Atherosclerosis in Oxford and Bern.
- Jan-Aug 2018: SNF Advanced Postdoc Mobility Grant. Returning phase. Stroke aetiology: Atherosclerosis in different vascular beds.
- Dec 2018: Bangerter Rhyner Stiftung. Grant. Low NIHSS score and therapy.
