Prof. Hironobu Ihn was born in 1964 at Kobe, Japan, and
received his Ph.D. and MD from the University of Tokyo in 1990. He worked as an
assistant professor in the Department of Dermatology, Faculty of Medicine, the The University of Tokyo in 1990, and as the research fellow in Division of
Rheumatology & Immunology, Medical University of South Carolina, SC, the
USA between 1994 and 1997. He served as the lecturer, Department of
Dermatology, Faculty of Medicine between 2001 and 2005, and became the
associate professor, Department of Dermatology, Faculty of Medicine, University
of Tokyo.
Prof. Hironobu Ihn was elected as the Professor &
Chairman, Department of Dermatology & Plastic Surgery, Faculty Life
Sciences, Kumamoto University in 2005, and became the Vice President, Kumamoto
University Hospital in 2013. He was awarded the Japanese Society of Connective
Tissue Research Award in 2001, the Japanese Society of Investigative
Dermatology Award in 2005, and the Japan Rheumatism Foundation Award in 2006.
- Yoshino Y, Ohtsuka M, Kawaguchi M, Sakai K, Hashimoto A, Hayashi M, Madokoro N, Asano Y, Abe M, Ishii T, Isei T, Ito T, Inoue Y, Imafuku S, Irisawa R, Ohtsuka M, Ogawa F, Kadono T, Kawakami T, Kukino R, Kono T, Kodera M, Takahara M, Tanioka M, Nakanishi T, Nakamura Y, Hasegawa M, Fujimoto M, Fujiwara H, Maekawa T, Matsuo K, Yamasaki O, Le Pavoux A, Tachibana T, Ihn H. The woud/ burn guidelines – 6: Guidelines for management of burns. J Dermatol, 43: 989-1010, 2016.
- Koga A, Kajihara I, Yamada S, Makino K, Ichihara A, Aoi J, Makino T, Fukushima S, Jinnin M, Ihn H. Enhanced CCR9 expression levels in psoriatic skin are associated with poor clinical outcome to infliximab treatment. J Dermatol, 43: 522-525, 2016.
- Uchihara T, Imamura Y, Iwagami S, Kajihara I, Kanemaru H, Karashima R, Ida S, Ishimoto T, Baba Y, Sakamoto Y, Miyamoto Y, Yoshida N, Watanabe M, Iyama K, Ihn H, Baba H. Small bowel perforation due to indistinguishable metasatsis of angiosarcoma: case report and brief literature review. Surg Case Rep 2: 42, 2016.
- Johno T, Egawa K, Jinnin M, Fukushima S, Masuguchi S, Inoue Y, Ihn H. Clinical usefulness of immunostaining with CEA in distinction between malignant melanoma and Spitz nevus. Invest Dermatol Venereol Res 2: 1-4, 2016.
- Noguchi H, Hiruma M, Miyashita A, Makino K, Miyata K, Ihn H. A case of fingernail onychomycosis due to Aspergillus flavus. Medical Mycol J, 57: E21-E25, 2016.
- Nakamura K, Jinnin M, Kudo H, Inoue K, Nakayama W, Honda N, Kajihara I, Masuguchi S, Fukushima S, Ihn H. The role of PSMB9 up-regulation by interferon signature in the pathophysiology of cutaneous lesions of dermatomyositis and lupus erythematosus. Br J Dermatol, 174: 1030-1041, 2016.
- Inoue M, Jinnin M, Wang Z, Nakamura K, Inoue K, Ichihara A, Moriya C, Sakai K, Fukushima S, Ihn H. microRNA level is raised in the hair shafts of patients with dermatomyositis in comparison with normal subjects and patients wuth scleroderma. Int J Dermatol, 55: 786-790, 2016.
- Kimura T, Fukushima S, Miyashita A, Aoi J, Jinnin M, Kosaka T, Ando Y, Matsukawa M, Inoue H, Kiyotani K, Park J-H, Nakamura Y, Ihn H. Myasthenic crisis and polymyositis induced by one dose of nivolumab. Cancer Sci, 107: 1055-1058, 2016.
- Yamada S, Jinnin M, Kajihara I, Nakashima T, Aoi J, Harada M, Igata T, Masuguchi S, Fukushima S, Ihn H. Cytokine expression profiles in the sera of cutaneous squamous cell carcinoma patients. Drug Discov Ther, 10: 172-176, 2016.
- Noguchi H, Hirum M, Maruo K, Jono M, Miyata K, Tanaka H, Tanabe K, Miyazaki Y, Ihn H. Localized cutaneous cryptococcosis: Summary of reported cases in Japan. Med Mycol J 57: E35-E39, 2016.
- Nakamura K, Jinnin M, Harada M, Kudo H, Nakayama W, Inoue K, Ogata A, Kajihara I, Fukushima S, Ihn H. Altered expression of CD63 and exomes in scleroderma dermal fibroblasts. J Dermatol Sci, 84: 30-39, 2016.
- Inoue H, Park JH, Kiyotani K, Zewde M, Miyashita A,Jinnin M, Kiniwa Y, Okuyama R, Tanaka R, Fujisawa Y, Kato H, Morita A, Asai J, Katoh N, Yokota K, Akiyama M, Ihn H, Fukushima S, Nakamura Y. Intratumoral expression levels of PD-L1, GZMA, and HLA-A along with oligoclonal T cell expansion associate with response to nivolmab in metastatic melanomas. Oncoimmunology 5: e1204507, 2016.
- Tokuzumi A, Fukushima S, Miyashita A, Nakahara S, Kubo Y, Yamashita J, Harada M, Nakamura K, Kajihara I, Jinnin M, Ihn H. Cell divison cycle-associated protein 1 as a new melanoma-associated antigen. J Dermatol, 43: 1399-1405, 2016.
- Wang Z, Nakamura K, Jinnin M, Kudo H, Goto M, Era T, Kira T, Nakashima T, Fukushima S, Ihn H. Establishment and gene expression analysis of disease-derived induced pluripotent stem cells of scleroderma. J Dermatol Sci, 84: 186-196, 2016.
- Egashira S, Jinnin M, Harada M, Masuguchi S, Fukushima S, Ihn H. Exome sequence analysis of Kaposiform hemangioendothelioma: identification of putative driver mutations. An Bras Dermatol, 91: 748-753, 2016
- Kadono T, Furuta K, Nagai Y, Kanoh H, Sekine Y, Noda Y, Mizokami H, Kataoka H, Nakagawa H, Tanaka K, Daian T, Kurashige Y, Nakagami G, Makabe N, Sekine R, Takahasaki M, Yoshino K, Endo T, Hidaka M, Maeshige N, Kubota K, Motita T, Okuwa M, Miyajima M, Noguchi M, Kinoshita S, Sobue M, Matsui Y, Murooka Y, Ishida Y, Sugama J, Tachibana T, Inoue Y, Ihn H. JSPU Guidelines for the prevention and management of pressure ulcers (4 th Ed.). Jpn J PU 18: 455-554, 2016.
- Tanigawa H, Miyata K, Tian Z, Aoi J, Kadomatsu T, Fukushima S, Ogata A, Takeda N, Zhao J, Zhu S, Terada K, Endo M, Norinaga J, Sugizaki T, Sato M, Morioka MS, Manabe I, Mashimo Y, Hata A, Takemori Y, Yamamoto K, Murakami M, Araki K, Jinnin M, Ihn H, Oike Y. Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis. Sci Rep, 6: 34690, 2016.
- Nakahara S, Fukushima S, Yamashita J, Kubo Y, Tokuzumi A, Miyashita A, Harada M, Nakamura K, Jinnin M, Ihn H. AT-rich interaction domain-containing protein 3B is a new tumor marker for melanoma. Acta Derm Venereol, 96: 112-114, 2017.
- Hamaguchi Y, Sumida T, Kawaguchi Y, Ihn H, Tanaka S, Asano Y, Motegi S, Kuwana M, Endo H, Takehara K. Safety and tolerability of bosentan for digital ulcers in Japanese patients with systemic sclerosis: prospective, multicenter, open-labele study. J Dermatol, 44: 13-17, 2017.
- Nakayama W, Jinnin M, Tomizawa Y, Nakamura K, Kudo H, Inoue K, Makino K, Honda N, Kajihara I, Fukushima S, Ihn H. Dysregulated Interleukin-23 signalling contributes to the increased collagen production in scleroderma fibroblasts via balancing microRNA expression. Rheumatology, 56: 145-155, 2017.
- Noguchi H, Hiruma M, Matsumoto T, Kano R, Ihn H. Ungual hyalohyphomycosis caused by Fusarium proliferatum in an immunocompetent patient. J Dermatol, 44: 88-90, 2017.
- Amagai M, Ikeda S, Hashimoto T, Mizuashi M, Fujisawa A, Ihn H, Matsuzaki Y, Ohtsuka M, Fujiwara H, Furuta J, Tago O, Yamagami J, Tanikawa A, Uhara H, Morita A, Nakanishi G, Tani M, Aoyama Y, Makino E, Muto M, Manabe M, Konno T, Murata S, Izaki S, Watanabe H, Yamaguchi Y, Matsukura S, Seishima M, Habe K, Yoshida Y, Kaneko S, Shindo H, Nakajima K, Kanekura T, Takahashi K, Kitajima Y, Hashimoto K. A randomized double-blind trial of intranenous immunoglobulin for bullous pemphigoid. J Dermatol Sci, 85: 77-84, 2017.
- Harada M, Jinnin M, Wang Z, Hirano A, Tomizawa Y, Kira T, Igata T, Masuguchi S, Fukushima S, Ihn H. The expression of miR-124 increases in aged skin to cause cell senecense and it decreases in squamous cell carcinoma. Biosci Trends, 10: 454-459, 2017.
- Wang Z, Jinnin M, Harada M, Kudo H, Inoue K, Nakayama W, Honda N, Makino K, Kajihara I, Fukushima S, Ihn H. Diagnosis of nail psoriasis: evaluation of nail-derived microRNAs as potential novel biomarkers. Eur J Dermatol, 27: 20-27, 2017.
- Maeda S, Kajihara I, Ogata A, Johno T, Jinnin M, Ihn H. Bromoderma in a pituitary adenoma patient treated with bromocriptine. J Dermatol, 44: e95-e96, 2017.
- Egashira S, Kajihara I, Kanemaru H, Uemura-Kiyohara M, Yamada-Kanazawa S, Nakahara S, Nagamoto E, Fukushima S, Jinnin M, Inoue Y, Ihn H. Achieved good response of S-1 and docetaxel combination chemotherapy in two patients with metastatic extramammary Paget’s disease. J Dermatol, 44: e103-e104, 2017.
- Saeki H, Nakagawa H, Nakajo K, Ishii T, Morisaki Y, Aoki T, Cameron GS, Osuntokun OO, Akasaka T, Asano Y, Etoh T, Fujita Y, Hashimoto T, higashiyama M, Igarashi A, Ihn H, Iwatsuki K, Kabashima K, Kawada A, Kawashima M, Nakamura K, Okubo Y, Okuyama R, Ozawa A, Sayama K, Seishima M, Shiohara T, Takahara M, Takahashi H, Takehara K, Tanase K, Tani M, Umezawa Y, watanabe H, Yamanaka K. Efficacy and safety of ixekizumab treatment for Japanese patients with moderate to severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis: Results from a 52-week, open-label, phase 3 study (UNCOVER-J). J Dermatol, 44: 355-362, 2017.
- Noguchi H, Hiruma M, Matsumoto T, Yaguchi T, Sano A, Mitsui N, Watanabe S, Ihn H. Subcutaneous cystic phaeohyphomycosis due to Pleurostomophora richardiae. J Dermatol, 44: e62-e63, 2017.
- Yamazaki N, Takenouchi N, Fujimoto M, Ihn H, Uchi H, Inozume T, Kiyohara Y, Uhara H, Nakagawa K, Furukawa H, Wada H, Noguchi K, Shimamoto T, Yokota K. Phase 1b study of pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in Japanese patients with advanced melanoma (KEYNOTE-041). Cancer Chemother Pharmacol, 79: 651-660, 2017.
- Torii H, Nakano M, Yano T, Kadono K, Nakagawa H, Fujita Y, Horie K, Ito M, Iitani M, Ito K, Kaneko T, Akasaka T, Ohtsuki M, Yasuda M, Abe M, Tanida Y, Terui T, Arai S, Nakano T, Etoh T, Asano Y, Umezawa Y, Saeki H, Adachi M, Seishima M, Tokura Y, Morita A, Yamanaka K, Tani M, Tanimura H, Yamazaki F, Nishigori C, Kaneko S, Muto M, Nakamura M, Hino R, Nakayama J, Nakano T, Utani A, Sato T, Ihn H. Efficacy and safety of dose escalation of infliximab therapy in Japanese patients with psoriasis: Results of the SPREAD study. J Dermatol, 44: 552-559, 2017.
- Terao C, Kawaguchi T, Dieude P, Varga J, Kuwana M, Hudson M, Kawaguchi Y, Matucci M, Ohmura K, Riemekasten G, Kawasaki A, Airo P, Horita T, Oka A, Hachulla E, Yoshifuji H, Japanese Scleroderma Genetic Consortium, Caramaschi P, Hunzelman N, Baron M, Hassouns P, Raychaudhuri S, Liao K, Gregersen P, Torii T, Tsuchiya N, Takehara K, Sato S, Ihn H, Riccieri V, Melchers I, Valentini G, Cauvet A, Martinez M, Mimori T, Matsuda F, Allanore Y. Trans-ethnic meta-analysis of genome-wide association study identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis. Ann Rheum Dis, 76: 1150-1158, 2017.
- Noguchi H, Hiruma M, Matsumoto T, Kano R, Tanaka M, Yaguchi T, Sonoda K, Ihn H. Fungal melanonychia: Ungual phaeohyphomycosis caused by Botryospheria dothidea. Acta Derm Venereol,97: 765-766, 2017.
- Noguchi H, Hiruma M, Matsumoto T, Yaguchi T, Tashima H, Ihn H. Multiple subcutaneous Candida abcesses on the palm and fingers in an immunocompetent patient. J Dermatol, 44: e174-e177.
- Sato Y, Kajihara I, Yamada-Kanazawa S, Jinnin M, Ihn H. S100A7 expression levels in coordination with IL-8 indicate the clinical response to infliximab for psoriasis patients. J Dermatol, 44: 838-839, 2017.
- Noguchi H, Hiruma M, Matsumoto T, Kano R, Ihn H. Ungual aspergillosis successfully treated with topical efinaconazole. J Dermatol, 44: 848-850, 2017.
- Yamazaki N, Kiyohara Y, Uhara H, Uehara J, Fujimoto M, Takenouhi T, Otsuka M, Uchi H, Ihn H, Minami H. Efficacy and safety of nivolumab in Japanese patients with previously untreated advanced melanoma: a phase II study. Cancer Sci, 108: 1223-1230, 2017.
- Yamazaki N, Kiyohara Y, Uhara H, Iizuka H, Uehara J, Ohtsuka F, Fujisawa Y, Tekenouchi T, Isei T, Iwatsuki K, Uchi H, Ihn H, Minami H, Tahara H. Cytokine biomarkers to predict antitumor responses to nivolumab suggested in a phase 2 study for advanced melanoma. Cancer Science, 1022-1031, 2017.
- Sawamura S, Kajihara I, Jinnin M, Honda Y, Ihn H. Cutaneous spindle cell adenolipoma on the nose: A rare variant of lipoma. J Dermatol, 44: e156-e157, 2017.
- Sawamura S, Jinnin M, Shimbara M, Nakamura K, Kudo H, Inoue K, Nakayama W, Kajihara I, Fukushima S, Ihn H. Serum levels of genomic DNA of ?1(I) collagen are elevated in scleroderma patients. J Dermatol, 44: 927-931, 2017.
- Higashi-Kuwata N, Ogata-Aoki H, Hattori SI, Hayshi H, Danish M, Aoki M, Shiotsu C, Kuwamura T, Ihn H, Kobayashi H, Okada S, Mitsuya H. Early phase dynamics of traceable mCherry fluorescent protein-carring HIV-1 infection in human peripheral blood mononuclear cells-transplanted NOD/SCID/Jak3-/- mice. Antiviral Res, 144: 83-92, 2017.
- Nakamura Y, Kajihara I, Yamada-Kanazawa S, Maeda-Otsuka S, Johno T, Aoi J, Igata T, Masuguchi S, Fukushima S, Jinnin M, Ihn H. Intratumor dihydropyrimidine dehydrogenase mRNA expression levels are decreased in extramammary Paget’s disease. Drug Discov Ther, 11: 152-155, 2017.
- Umezaki N, Ishimoto T, Koba I, Nakaya T, Mawatari M, Kuramoto K, Izumi D, Sakamoto Y, Miyamoto Y, Yoshida N, Watanabe M, Inoue Y, Ihn H, Baba H. Anorectal malignant melanoma with extensive intraepithelial extension: report of a case. Int Canc Conf J, in press
- Izumiya Y, Jinnin M, Kimura Y, Wang Z, Onoue Y, Hanatani S, Araki S, Ihn H, Ogawa H. Expression of Let-7 family microRNAs in skin correlates negatively with severity of pulmonary hypertension in patients with systemic scleroderma. Int J Cardiol Heart Vasc. 8: 98-102, 2017.
- Yamada-Kanazawa S, Kajihara I, Fukushima S, Jinnin M, Masuzawa M, Makuzawa M, Amoh Y, Hoshina D, Abe R, Ihn H. Inhibition of heat shock protein 90 exerts antitumor effect in angiosarcoma: involvement of the vascular endothelial growth factor signaling patway. Br J Dermatol, 177: 456-469, 2017 .
- Sawamura S, Kajihara I, Makino K, Makino T, Fukushima S, Jinnin M, Oyama B, Hashimoto T, Ihn H. Systemic lupus erythematosus associated with myasthenia gravis, pemphigus foliaceus and chronic thyroiditis after thymectomy. Australas J Dermatol, 58: e120-e122, 2017.
- Oka A, Asano Y, Hasegawa M, Fujimoto M, Ishikawa O, Kuwana M, Kawaguchi Y, Yamamoto T, Takahashi H, Goto D, Endo H, Jinnin M, Mano S, Hosomichi K, Mabuchi T, Ueda MT, Nakagawa S, Beck S, Bahram S, Takehara K, Sato S, Ihn H. RXRB is an MHC-encoded susceptibility gene associated with anti-topoisomerase I antibody-positive systemic sclerosis. J Invest Dermatol, 137: 1878-1886, 2017.
- Nakashima S, Jinnin M, Kanemaru H, Kajihara I, Igata T, Okamoto S, Tazaki Y, Harada M, Masuguchi S, Fukushima S, Masuzawa M, Amoh Y, Masuzawa M, Ihn H. Down-regulation of miR-210, E2F3 and Ephrin A3 in angiosarcoma cell proliferation. Eur J Dermatol, in press.
- Ide M, Jinnin M, Tomizawa Y, Wang Z, Kajihara I, Fukushima S, Hashizume Yno Y, Asano Y, Ihn H. Transforming growth factor ? inhibitor Repsox down-regulates collagen expression of scleroderma dermal fibroblasts and prevents bleomycin-induced mice skin fibrosis. Exp Dermatol, in press.
- Ichihara A, Jinnin M, Ihn H. Treatment of psoriasis with ustekinumab improved skin tightening in systemic sclerosis. Clin Exp Rheumatol, in press.
- Aoi J, Fukushima S, Jinnin M, Ihn H. Fluorescence in situ hybridization for diagnosis of malignant melanoma using RREB1, MyB, Cep 6, and CCND1 probes in Japanese patients. Dermatologica Sinica, in press.
- Abe M, Nishigori C, Torii H, Ihn H, Ito K, Nagaoka M, Isogawa N, Kawaguchi I, Tomochika Y, Kobayashi M, Tallman AM, Papp KA. Tofacitinib for the treatment of moderate to severe chronic plaque psoriasis in Japanese patients: Subgroup analyses from a randomized, placebo-controlled phase 3 trial. J Dermatol, in press.
- Kajihara I, Yamada-Kanazawa S, Maeda-Otsuka S, Jinnin M, Akaike K, Ihn H. Secukinumab-induced interstitial pneumonia in a patient with psoriasis vulgaris. J Dermatol, in press.
- Inoue M, Miyashita A, Noguchi H, Hirose N, Nishimura K, Masuda M, Ihn H. Human protothecosis in Japan: A belated case report with current status. J Dermatol, in press.
- Egashira S, Jinnin M, Ajino M, Shimozono N, Okamoto S, Tazaki Y, Hirano A, Ide M, Kijihara I, Aoi J, Harada M, Igata T, Masuguchi S, Fukushima S, Ihn H. Chronic sun exposure-related fusion oncogenes EGFR-PPARGC1A in cutaneous squamous cell carcinoma. Sci Rep, in press.
- Ogata-Aoki H, Higashi-Kuwata N, Hattori SI, Hayshi H, Danish M, Aoki M, Shiotsu C, Hashiguchi Y, Hamada A, Kobayashi H, Ihn H, Okada S, Mitsuya H. Raltegravir blocks the infectivity of red-fluorescent-protein (mCherry)-labeled HIV-1JR-FL in the setting of post-exposure prophylaxis in NOD/SCID/Jak3-/- mice transplanted with human PBMCs. Antiviral Res, in press.
- Noda-Yamashita T, Kajihara I, Kidou M, Ihn H. Dyskeratosis congenital associated with congenital hypothyroidism. J Dermatol, in press.
