Dr. Yuting Tan's research interests broadly involve in cancer, stem cell, and aging. During her Ph.D. research, she studied the epigenetic mechanisms of acute myeloid leukemia in Shanghai Jiao Tong University. Then she joined the University of California, San Francisco, as a joint Ph.D. student for two years, during which she studied the differentiation of induced pluripotent stem cells into hematopoietic stem and progenitor cells. Also, she manipulated the CRISPR/Cas9 tool to disrupt the drug resistance of leukemic oncogenes.
After her Ph.D. study, she was trained as a rotated resident in Rui Jin Hospital, where she studied the cancer immunotherapy for blood diseases and acquired the aspiration of studying cancer and aging. Therefore, she moved to Boston and became the research fellow in Massachusetts General Hospital affiliated with Harvard Medical School to study cancer and aging. Yuting Tan's research goal is to extend the life expectancy of a human being with delayed aging and the absence of cancer.
- Yu-Ting Tan, Han Liu, Sai-Juan Chen, 2015. Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property, a requisite of leukemia initiation and relapse. Front Med 9, 412-420.
- Yu-Ting Tan, Yan Sun, Shou-Hai Zhu, Lin Ye, Chun-Jun Zhao, Wei-Li Zhao, Zhu Chen, SaiJuan Chen*, Han Liu*, 2016. Deregulation of HOX genes by DNMT3A and MLL mutations converges on BMI1. Leukemia 30, 1609-1612.
- Lin Ye, Jiaming Wang, Yu-Ting Tan, Ashley I. Beyer, Fei Xie, Marcus O. Muench, Yuet W. Kan*, 2016. Genome editing using CRISPR-Cas9 to create the HPFH genotype in HSPCs: An approach for treating sickle cell disease and beta-thalassemia. Proc Natl Acad Sci U S A 113, 1066110665.
- Fei Xie, Kerui Gong, Ke Li, Mingliang Zhang, Judy C. Chang, Shizhong Jiang, Lin Ye, Jiaming Wang, Yuting Tan, Yuet Wai Kan, 2016. Reversible Immortalization Enables Seamless Transdifferentiation of Primary Fibroblasts into Other Lineage Cells. Stem Cells Dev 25:12431248.
- Yu-Ting Tan, Lin Ye, Fei Xie, Ashley I. Beyer, Marcus O. Muench, Jiaming Wang, Zhu Chen, Han Liu*, Sai-Juan Chen*, Yuet W. Kan*, 2018. Respecifying human iPSC-derived blood cells into highly engraftable hematopoietic stem and progenitor cells with a single factor. Proc Natl Acad Sci U S A 115, 2180-2185.
- Commentary. Bernd B. Zeisig, Chi Wai Eric So, 2018. MLL-AF4, a double-edged sword for iPSC respecification into HSPCs. Proc Natl Acad Sci U S A 115, 1964-1966 • Recommended by The Faculty of 1000.
- Dan Li, Yu-Tian Hu, Zhen Jin, You Zhai, Yu-Ting Tan, Yan Sun, Shou-Hai Zhu, Chun-Jun Zhao, Bing Chen, Jiang Zhu, Zhu Chen, Sai-Juan Chen, Jun-Min Li*, Han Liu*, 2018. Tan CAR T cells targeting CD19 and CD133 efficiently eliminate MLL leukemic cells. Leukemia 32, 20122016.
- Shouhai Zhu, Zhihong Chen, Ruiheng Wang, Yuting Tan, Maolin Ge, Yan Sun, Dan Li, Yutian Hu, Chunjun Zhao, Zhu Chen, Saijuan Chen, Han Liu, 2019. MLL is required for miRNA-mediated translational repression. Cell Discov.
- Yu-Ting Tan, Lin Ye, Fei Xie, Jiaming Wang, Markus Müschen, Sai-Juan Chen*, Yuet W. Kan*, Han Liu*, 2019. The CRISPR/Cas9-mediated gene deletion efficiently retards the progression of Philadelphia-positive acute lymphoblastic leukemia in a p210 BCR-ABL1T315I mutation mouse model. Haematologica. 2019.229013.
- 2009: First Prize Scholarship of Hunan Normal University.
- 2009: First Prize of National College English Contest.
- 2009: First Prize in Hunan Province and National Top 20 of China Central Television.‘Star of Hope’ Oral English Competition.
- 2009: Outstanding Student Union Cadres.
- 2010: National Scholarship. First Prize Scholarship of Hunan Normal University.
- 2011: First Prize Scholarship of Hunan Normal University.
- 2012: First Prize Scholarship of Hunan Normal University.
- 2013: Outstanding University Graduate of Hunan Province.
- 2014: Second Prize Scholarship of Shanghai Jiao Tong University School of Medicine.
- 2015: First-grade School Scholarship of Shanghai Jiao Tong University.
- 2015: Joint PhD Scholarship under the State Scholarship Fund from China Scholarship. Council (Ranking No.1 at Shanghai Jiao Tong University School of Medicine).
- 2017: Top Grade Award of 2017 ‘Bo Ji Yi Yuan’ Graduate Student Academic Forum of Shanghai Jiao Tong University School of Medicine.
- 2017: First Prize of 2017 ‘Zhu Chen and Sai-Juan Chen Award For Graduate Student’ of Shanghai Institute of Hematology.
- 2017: ‘Student of the Year’ of Shanghai Jiao Tong University (Ranking No.1 at Shanghai Jiao Tong University).
- 2018: President’s Award of Shanghai Jiao Tong University.
- 2018: ‘Star of Self-Empowerment Pacesetter of China’s University Student’ (1 out of 10 awardees of the nation).
- 2018: PhD representative of China for attending 68th Lindau Nobel Laureate Meeting.
- 2018: ‘Student of the Year as the Model’ of Shanghai Jiao Tong University School of Medicine.
- 2018: Outstanding University Graduate of Shanghai.
- 2019: Outstanding PhD Dissertation of Shanghai Jiao Tong University (1 out of 15 awardees of the university).
