Dr. Mehmet Sitki Copur is a nationally known medical oncologist. He is an adjunct faculty professor at the University of Nebraska Medical Center Department of Internal Medicine Division of Hematology/Oncology. He graduated from medical school at Hacettepe University in Ankara, Turkey.
M. Sitki Copur served an Internal Medicine Residency, also in Turkey, before completing an internship and residency, both at Chicago Medical School in Chicago. His medical oncology fellowship was at the National Cancer Institute in Bethesda, Maryland. He is board certified in Internal Medicine and Medical Oncology, and serves on numerous committees.
- 1992-1995: Medical Oncology Fellowship-National Cancer Institute, National Institutes of Health, Bethesda, MD.
- 1990–1992: Residency-Chicago Medical School, University of Health Sciences, Internal Medicine, Chicago IL.
- 1989–1990: Internship-Chicago Medical School, University of Health Sciences, Internal Medicine, Chicago, IL.
- 1985–1989: Internal Medicine Residency, Hacettepe University Faculty of Medicine, Ankara, Turkey.
- 1984–1985: Primary Care medicine in a Military Garrison, Agri, Turkey (Mandatory Military Service).
- 1982-1984: Primary Care Medicine in a rural area, Carsamba, Turkey (Mandatory Civil Service).
- 1976-1982: Medical School-Hacettepe University, Faculty of Medicine, Ankara, Turkey. Degree Granted: M.D.
- Copur MS. Inadequate Awareness of and Participation in Cancer Clinical Trials in the Community Oncology Setting. Oncology February 2019;33(2).
- Copur MS et al. 49-year-old man with pathologic hip fracture and widespread metastatic lytic lesions in his bone. Case Quandaries. Oncology Cancer Network, January 2019.
- Freedman DH. Clinical Trials in the Rural Community Oncology Setting. Scientific American January 2019.
- Copur MS. I live to Conquer Cancer. ASCO connection Aug 2018. https://connection.asco.org/magazine/i-live-conquer-cancer/i-live-conquer-cancer-dr-mehmet-sitki-copur.
- Copur MS. Adjuvant FOLFOX Improved DFS in yp Stage II Rectal Cancer. Commentary. Oncology CancerNetwork, June 6, 2018.
- Copur MS. Second-Line Irinotecan /Cetuximab/RamucirumabCombo Ups PFS in Advanced CRC. Commentary. Oncology CancerNetowrk,June 6,2018.
- Venetoclax-Rituximab in Chronic Lymphocytic Leukemia. Copur MS, Gauchan D, Crockett D. N Engl J Med 2018; 378:2142-2143.
- Copur MS, Qureishi HN. Ulcerated nodular skin lesion on a 30 year old man on posterior thigh. Oncology 2018 Cancer Network.
- Sohal DPS, Kennedy EB, Khorona A, Copur MS et al. Metastatic pancreatic cancer: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol 2018; May 23:JCO2018789636. 0/JCO.2018.78.9636.
- Copur MS, Crockett D, Gauchan D, Ramaekers R, Mleczko K. Molecular Testing Guideline for the Selection of Patients With Lung Cancer for Targeted Therapy.JClinOncol. 2018 Jul 1;36(19):2006.
- Copur MS, Gauchan D, Ramaekers R Durvalumab in Stage III Non-Small-Cell Lung Cancer.NEngl J Med. 2018 Mar 1;378(9):868.
- Copur MS, Gnewuch C, Schriner M, Tharnish M, Gonen M, McDonald M, Kezeor J, Ramaekers RC, Potential cost savings by dose down-rounding of monoclonal antibodies in a community cancer center.J Oncol Pharm Pract. 2018 Mar;24(2):116-120.
- Copur MS, Wurdeman JM, Nelson D, Ramaekers R, Gauchan D, Crockett D.Normalization of Elevated Tumor Marker CA27-29 after Bilateral Lung Transplantation in a patient with Breast Cancer and Idiopathic Pulmonary Fibrosis.Oncol Res. 2017 Dec 11.
- Copur MS, Ramaekers R, Gauchan D, Crockett D, Clark D.Synchronous Bilateral Breast Cancer With Discordant Histology.Oncology (Williston Park). 2017 Apr 15;31(4):274-7, 312.
- Copur MS, Ramaekers R, Crockett D. Ipilimumab Adjuvant Therapy in Melanoma. N EnglJ Med. 2017 Jan 26; 376(4):398-399.
- Copur MS, Schneider S, Mleczko K, Hadford D, Clark D. Woman With Rare Cause of Rectal Bleeding.Oncology (Williston Park). 2018 Jan 15;32(1):28-31.
- Copur MS, Gauchan D, Ramaekers R, Crockett D, Clark D. Neoadjuvant Chemotherapy or Primary Debulking Surgery for Stage IIIC Ovarian Cancer.J Clin Oncol. 2017 Mar;35(7):802-803.
- Copur MS, Ramaekers R, Gauchan D, Norvell M, Clark D Recent ASCO Guideline on the Use of Biomarkers for Adjuvant Systemic Therapy in Early-Stage Invasive Breast Cancer.J Clin Oncol. 2016 Aug 22. pii: JCO682385.
- Huerter MM, Meza JL, Copur MS, Tolentino A, Marr AS, Ketcham M, DeSpiegelaere H, Kruse S, Kos ME, Swenson K, Radniecki SE, Kessinger A, Ganti AK. Weekly vinorelbine and paclitaxel in older patients with advanced non-small cell lung cancer: A phase II Fred and Pamela Buffet Cancer Center Clinical Trials Network study.J GeriatrOncol. 2017 Jan;8(1):18-22.
- Sohal DP, Mangu PB, Khorana AA, Shah MA, Philip PA, O'Reilly EM, Uronis HE, Ramanathan RK, Crane CH, Engebretson A, Ruggiero JT, Copur MS, Lau M, Urba S, Laheru D.Metastatic Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline.J Clin Oncol. 2016 May 31. pii: JCO671412. [Epub ahead of print].
- Copur MS, Ramaekers R, Clark D, Norvell M, Gauchan D.Is It Time to Reconsider Prophylactic Cranial Radiation in Non-Small-Cell Lung Cancer?J Clin Oncol. 2016 Jul 1;34(19):2314.
- Douglas Clark D, Gauchan D, Ramaekers R, Norvell M, Copur MS. Radiation Recall Pneumonitis during Systemic Treatment with Everolimus. Oncology Research 2015; 22:321-324.
- Copur MS, Ramaekers R, Gonen M et al.Impact of the NCI Community Centers Program (NCCCP) on clinical trial and related activities in a community center in rural Nebraska. J OncolPract 2015Aug 11. pii: JOP.2015.005736. [Epub ahead of print.).
- Jamison C, Nelson D, Eren M, Gauchan D, Ramaekers R, Norvell M Copur MS et al. What is the optimal dose and schedule for dasatinib in Chronic Myeloid Leukemia; two case reports and review of the literature. Oncology Research 2016;23:1-5.
- Copur MS, Gauchan D, Brussow K et al. Germline BRCA1/2 mutations: are they good enough todetermine who will respond to Poly(ADP-Ribose) Polymerase inhibitor therapy in advanced cancer. J Clin Oncol 2015Aug 10;33(23):2583-4.
- Gauchan D, Ramaekers R, Copur SM. Cost-effectiveness of molecular profiling for early breast cancer. J Clin Oncol 2015; 33(14):1627-8.
- Islam KM, Opoku ST, Apentent BA, Fetick A, Ryan J, Copur M et al. Engaging Patients and Caregivers in Patient-Centered Outcomes Research on Advanced Stage Lung Cancer; Insights from Patients, Caregivers and Providers. J CancEduc.
- Islam KM. Copur M. Tolentino A et al. Patient-Centered Outcomes Research in Advanced Stage Lung Cancer: Study design and population. Int J Cancer Studies & Research ISSN:2167-9118.
- Lee M. Ellis, David S. Bernstein, Emile E. Voest et al. American Society of Clincal Oncology Perspective: Raising the Bar for Clincal Trials by Defining Clincally Meaningful Outcomes J Clin Oncol 2014.
- Copur MS, Faller B, Good M, Graham P et al. ASCO Research Program Quality Assessment Tool – www.asco.org/communityresearchforum.
- Islam KM, Opoku ST, Apentent BA, Fetrick A, Ryan J, Copur M, Tolentino A, Vaziri I, Ganti AK. Engaging Patients and Caregivers in Patient-Centered Outcomes Research on Advanced Stage Lung Cance: Insights from Patients, Caregivers and Providers. J Cancer Educ. 2014 Apr 18 (Epub ahead of print).
- Pazopanib versus Sunitinib in Renal Cancer. Ramaekers R, Tharnish M, Copur MS. N Engl J Med 2013 Nov 14;369(20):1968-9.
- Ramaekers R, Jabbour M, Copur MS. Anastrozole and Fulvestrant in Metastatic Breast Cancer. N Engl J Med 2012;367(17):1662-3.
- Copur MS, Obermiller A, Ramaekers R. Incorporation of Bevacizumab in the Primary Treatment of Ovarian Cancer. N Engl J Med 2012;366:1256-1257.
- Behne T, Copur MS. Biomarkers for Hepatocellular Carcinoma. Intern J HepatolInternational Journal of Hepatology 2012, Article ID 859076.
- Copur MS, Obermiller AM, Ramaekers R et al. Letrozole and Fulvestrant Combination in Second Line or More for Estrogen Receptor Positive Metastatic Breast Cancer. Efficacy and Predictive Factors of Response. Copur et al. J Cancer SciTher 2011, S2 http://dx.
- Copur MS, Obermiller A. Ipilimumab Plus Dacarbazine in Melannoma. N Engl J Med 2011;365:1256-1257.
- Sherman S, Shats O, Fleissner E, Bascom G, Yiee K, Copur M et al. Multicenter Breast Cancer Collaborative Registry. Cancer Informatics 2011;10:217-226.
- Obermiller AM, Copur MS. The Longstanding Quest for a Better Endocrine Therapy Continues High Dose Fulvestrant: Have we found the effective dose, combination, stting or sequence. Contemporary Oncology 2011; 34-37.
- Obermiller A, Copur MS. Fulvestrant High Dose versus Loading Dose versus Approved Dose, Have we found the optimum dose?. Clin Breast Cancer 2011;11:195.
- Copur MS, Obermiller A. An Algorithm for the Effective Management of Hypertension in the Setting of Vascular Endothelial Graowth Factor Signaling Inhibition. Clin Colorectal Cancer 2011:10:151-156.
- Kummar S, Copur MS, Rose M, Wadler S, Stephenson J, O’Rourke M, Brenckman M, Tilton R, Liu S-H, Jiang Z, Su T, Cheng Y, Chu E. A Phase I Study of the Chinese Herbal Medicine PHY906 as a Modulator of Irinotecan-Based Chemotherapy in Patients with Advanced Colorectal Cancer. Clin Colorectal Cancer 2011;10:85-96.
- Copur MS, Obermiller A. Largest Randomized Trial of Biliary Tract Cancer Treatment with Cisplatin plus Gemcitabine versus Gemcitabine Alone: An excellent opportunity to evaluate the prognostic value of tumor marker Cal19-9. Clin Colorectal Cancer 2011;10:70-71.
- Saif MW, Kaley K, Chu Em, Copur MS. Safety and Efficacy of Panitumumab Therapy after Progression with Cetuximab Experience at two Institutions. Clin Colorectal Cancer 2010;9:315-318.
- Robert NJ, Saleh MN, Paul; D, Generali D, Gressot L, Copur MS et al. Sunitinib Plus Paclitaxel versus Bevacizumab Plus Paclitaxel for First-Line Treatmentof Patients with Advanced Breast Cancer; A Phalse III, Randomized, Open-label trial. Clin Breast Cancer 2011;11:82-89.
- Copur MS. Impact of Older Age on the Efficacy of Newer Adjuvant Chemotherapy Regimens in Colon Cancer, a Subgroup Analysis of a Meta-analysis: Practice Changing? Certainly not; Hypotheses Generating? Perhaps Clin Colorectal Cancer. 2009 Oct;8(4)190.
- Abuzetun JY, Loberiza F, Vose J, Bierman P, Bociek RG, Enke C, Bast M, Weisenburger D, Armigage JO; Copur MS Nebraska Lymphoma Study Group. The Stanford V Regimen is Effective in Patients with Good Risk Hodgkin Lymphoma but Radiotherapy is a Necessary Component. Br J Haematol. 2009 Feb;144(4)531-7.
- Copur MS, Norvell M, Obermiller A. Chemotherapy and Immunotherapy in Metastatic Colorectal Cancer. N Eng J Med 2009;360:2135.
- Copur MS. Sorafenib in Advanced Hepatocellular Carcinoma. N Eng J Me4d 2008;359:2498-9.
- Copur MS, Deshpande A, Mleczko K, Norvell M, Hrnicek GJ, Woodward S, Frankforter S, Mandolfo N, Fu K, Chan WC. Full Clincial Recover after Topical Acyclovir Treatment of Epstein-Barr Virus Associated Cutaneous B-Cell Lymphomoa in Patient with Mycosis Fungoides. Croat Med J 2005;46:458-462.
- Copur MS, Ledakis P, Novinski D, Fu K, Hutchins M, Frankforter s, Mleczko, Sanger G, Wing CC. An Unusual Case of Coposite Lymphoma Involving Chronic Lymphocyticleukemia Follicular Lymphoma and Hodgkin Disease. Leukemia & Lymphoma 45(4):1071-1076:2004.
- Maung K, Copur MS, Jain VK. New Strategies for the Treatment of Chemotherapy Induced Diarrhea. Supportive Cancer Therapy 1(2);70-74:2004.
- Hightower M, Klem J, Lee D, Chu E, Copur S, Vain KJ. Highlights from 14th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. ClinCiolorectal Cancer 3(1);10-14:2003.
- Maung K, Lee D, DeGrendele HC, Schlisky R, Chu E, Jain VK, Copur S. Highlights from 27th Congress of the European Society for Medical Oncology. Nice, France October, 18-22, 2002. Clin Colorectal Cancer. 2(3);140-145:2002.
- Copur MS, Ledakis P, Bolton M. Molecular Profiling of Lymphoma. N Eng J Med 347;1376-1377:2002.
- Copur MS, Ledakis P, Norvell M. Nephrectomy for Metastatic Renal-Cell Cancer. N Eng J Med 346;1095-1096:2002.
- Copur MS, Chu E. Thymidylate Synthase Pharmacogenetics in Colorectal Cancer. Clin Colorectal Cancer 1(3);179-180:2001.
- Copur MS, Ledakis P, Bolton M, Morse AK, Werner T, Norvell M, Muhvic J, Chu E. An Adverse Interaction between Warfarin and Capecitabine; A Case Report and Review of the Literature. Clin Colorectal Cancer 1 (3);182-184:2001.
- Copur MS, Ledakis P, Bolton M, Norvell M, Muhvic J. Is Anastrozole Superior to Tamoxifen. J Clin Oncol, 19;2578-2581:2001.
- Copur MS, Ledakis P, Novinski D, Mleczko K, Frankforter S, Bolton M, Fruehling R, Van Wie E, Norvell M, Muhvic J. Squamous Cell Carcinoma of the Colon with an Elevated Serum Squamous Cell Carcinoma Antigen Responding to Combination Chemotherapy. Clin Colorectal Cancer 1;55-58:2001.
- Copur S, Ledakis, P, Lynch J, Hauke R, Tarantolo S, Bolton M, Norvell M, Muhvic J, Hake I, Wendt J. Weekly Docetaxel and Estramustine in Patients with Hormone Refractory Prostate Cancer. SeminOncol 28(4);16-21:2001.
- Copur S, Ledakis P, Muhvic J. Fludarabine for Chronic Lymphocytic Leukemia. N Eng J Med 344;1166-1168:2001.
- Copur S, Matamoros A, Capadano M, Goertzen T, Brand R, Lynch JC, Tempero M. Alternating Hepatic Arterial Infusion and Systemic Chemotherapy for Liver Metastases from Colorectal Cancer: A Phase II Trial Using Intermittent Percutaneous Hepatic Arterial Access. J Clin Oncol 19;2404-2412:2001.
- Copur MS, Ledakis P, Norvell M. Prevention of Delayed Emesis Caused by Chemotherapy. N Engl J Med 343(12):888-890:2000.
- Copur MS, Ledakis P, Muhvic J. Patients 65 Years of age or Older in Cancer Treatment Trials. N Eng J Med 342(20);1531:2000.
- Copur MS, Ledakis P, Novinski D, Bolton M,. Two Cases of Hormone Refractory Prostate Cancer Treated with Weekly Docetaxel/Estramustine. Case Stud Onc 2;2-6:2000.
- Copur MS, Ledakis P,. Weekly Docetaxel and Estramustine in Hormone Refractory Prostate Cancer. Can Con Highlights, 4;6-9:2000.
- Lin X, Mizunuma N, Chen T, Copur SM, Maley G, Liu J, Maley F, Chu E. InVitro Selection of an RNA Sequence that Interacts with High-Affinity with Thymidlylate Synthase. Nucleic Acid Res 28;4266-4274:2000.
- Chu E, Schmitz JC, Ju J, Copur SM. An Immunoprecipitation-RNA:rPCR Method for the In Vivo Isolation of Ribonucleoprotein Complexes. Methods Mol Biol. 118;’265-274:1999.
- Chu E, Copur S, Ju J, Chjen TM, Khleif S, Voeller DM, Mizunuma N, Patel M, Maley G, Maley F, Allegra CJ. Thymidylate Synthase Protein and P53 mRNA from and In Vivo Ribonucleoprotein Complex, Mol Cell Biol 19(2):1582-1594:1999.
- Chu E, Cogliati T, Copur SM, Borre A, Allegra CJ, Segal S. Identification of In Vivo Target RNA Sequences Bound by Thymidylate Synthase. Nucleic Acid Res 24(16)3222-3228:1996.
- Copur SM, Aiba K, Drake JC, Allegra CJ. ThymidylateSyntase Gene Amplification in Human Colon Cancer cell Lines Resistant to 5-Fluorouacil. BiochemPharmacol 49;1419-1426:1995.
- Copur S, DahutWm Chu E, Allegra CJ. Bone Marrow Aplasia and Severe Skin Rash after a Single Low Dose of Methotrexate. Anti-Cancer Drugs 6;154-157:1995.
- Chu E, Takechi T, Jones KL, Voeller DM, Copur SM, Maley GF, Maley F, Segal S, Allegra CJ. Thymidylate Synthase Protein Binds to c-myc RNA in Human Colong Cancer Cells and In Vitro. Mol Cell Biol 15(1):179-185:1995.
- Bawani M, Tibrewala S, Copur S, Harris D. DNA Flow Cytometry of Colorectal Carcinoma: Correlation of DNA Stemlines to other Prognostic Indices. Amer J Gastroenterology 86(2):191-195:1990.
- Copur S, Sozen T. The Primary Empty Sella Syndrome. Analysis of Twelve Patients. Hacet Med J 24:63-68:1990.
- Copur S, Bayraktar Y, Ozenc A, Aran O Kucukali T, Tleatar H. Carcinoid Tumors and Carcinoid Syndrome Twenty Years Experience at Hacettepe University Hospitals. Hacet Med J 23:158-162:1990.
- Sozen T, Copur S, Sayinalp S. Primary Empty Sella Syndrome and Panhypopitutarism. Hacettepe Tip Dergisi 4:76-82:1990.
- Copur S, Oner K, Ozturk C, Basr Y, Baris I. Digital Clubbing in Pulmonary Tuberculosis Patients. TurkiyeKlinikleriArastirmaDergisi 7:347-350:1989.
- Copur S, Kus S, Kars A, Renda N, Tekuzman G, Firat D. Lactate Dehydrogenase and its Isoenzymes in Serum from Patients with Multiple Myeloma. Clin Chem 356(9):1967-1970:1989.
- Copur S, Tasdemir I, Turgan C, Yasavul U, Caglar S. Effects of Nitrendipine on Blood Pressure and Blood Cyclosporin A Levels in Patients with Post-transplant Hypertension. Nephron 52(3);227-230:1989.
- Copur S, Oto A, Oram E, Ugurlu S, Oram A Turgan C, Catlar S. The Effects of Low Osmolality Contrast Medium (ultravist R)on Osmotic Diuresis. Hacettepe Med J 21:103-108:1988.
- Ozdemir O, Copur S, Kars A, Ruacan S, Tekuzman G, Firat D. Mutiple Primary Malignancies: Three Case Reports and a Review of the Literature. Turk J Can 18(2):77-82:1988.
- Bayraktar Y, Copur S, Batman F, Gokoz A, Telatar H. Benign Lymphoid Hyperplasia of the Stomach (Gastric Pseudolymphoma). Ankara Tip Bulteni 10(4):453-460:1988.
- Copur S, Kars A, Tekuzman G, Alakavuklar M, Baltali E, Firat D. Carcinoma of Male Breast. Turk J Can 18(2):72-76:1988.
- Copur S, Tokgozoglu L, Oto A, Oram E, Ugurlu S. Effects of Oral Prazosin on Total Plasma Digoxin Levels. FundamCliPharmacol 2:13-17:1988.
- Guran S, Balkanci F, Copur S, Tasdemir I, Oran M, Yasavul U, Turgan C, Erol A, Caglar S. Renal Ultrasonograpy Findings in Chronic Hemodialysis Patients. Hacettepe Tip Dergisi 21(4):263-272:1988.
- Batman F, Copur S. Effects of Smoking on Gastrointestinal Tract. Yeni Tip Dergisi 5:19-22:1988.
- Copur S, Oto A, Nazli N, Oram E, Urgurlu S, Oram A, Turgan C, Caglar S. Effects of Radiographic Contrast Dye on Renal Function. IcHastaliklariDergisi 2:115-118:1987.
- Yavuz H, Copur S, Tasdemir I, Yasavul U, Turgan C, Batman F, Caglar S, Bakkaloglu M. A Case of Renal Artery Stenosis, Normal Blood Pressure and Polycythemia. Hacet Tip Dergisi 20(3): 189-192:1987.
- Ulutan F, Copur S, Kocoglu T. The Fungal Flora of the air in Northern Turkey. MikrobiolojiBulteni 19:139-143:1985.
- 2019: Scientific American Recognition for Rural Clinical Trials Service.
- 2018: NCI Gold Medal from NCORP clinical trial enrollment for CHI-NCORP.
- 2018: NCI Silver Medal for NCORP clinical trial enrollment for St Francis.
- 2017: Physician of the Year Award for Third City Community Clinic.
- 2017: NCI Gold Medal for NCORP clinical trial enrollment.
- 2017: American College of Surgeons Outstanding Achievement Award.
- 2016: ASCO Clinical Trial Participation Award(Second Time).
- 2014: NCI Community Cancer Centers Program Certificate of Appreciation.
- 2014: American College of Surgeons Outstanding Achievement Award.
- 2013: American Cancer Society Health Care Excellence Award.
- 2013: CHI National Oncology Service Line Certificate of Appreciation for Chemotherapy Order Library Development.
- 2013: American Cancer Society Distinguished Service Award.
- 2012: National Accreditation Program for Breast Centers of Excellence.
- 2010: American College of Surgeons Outstanding Achievement Award.
- 2010: ASCO Clinical Trial Participation Award (First Time).
- 2009: Physician Excellence Award, Saint Francis Medical Center.
- 2001: Nebraska Lymphoma Study Group Award.
- 2000: Mother Bonzel Award Nomination, Saint Francis Medical Center.
- 1995: National Institutes of Health, National Cancer Institute-Award for Research Excellence.
- 1989: SerefZileli Prize-Best Internal Medicine Resident of the year at Hacettepe University Faculty of Medicine.
- 1989: Sandoz Scientific Prize.
- 2014-Present: National Cancer Institute Community Oncology Research Grant-NCORP, Principal Investigator.
- 2007-2016: Breast Cancer Collaborative registry.
- 2012-2014: PCORI – through NCI/UNMC.
- 2011-2012: Outreach Risk Awareness Project Grant - Susan G. Komen Foundation.
- 2010-2011: American Society of Clinical Oncology Community Oncology Research Support Grant.
- 2007-2012: National Cancer Institute Community Cancer Center Pilot (NCCCP).
- 2002-2003: Breast Cancer Awareness Project Grant – Susan G. Komen Foundation.
