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Shigeo Masuda

Shigeo Masuda

Shigeo Masuda

MD, PhD Osaka University Graduate School of Medicine, Department of Cardiovascular Surgery Japan

BIOGRAPHY 3 PUBLICATIONS 62 ACCOMPLISHMENTS 60

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Dr. Shigeo Masuda received his MD from the University of Tokyo in 1996, and PhD in Hematology/Oncology from the Graduate School of Medicine, University of Tokyo, Japan.

Dr. Shigeo Masuda was an Assistant Professor and an Associate Professor at Jichi Medical University, Japan, from 2007 to 2012, and joined RIKEN CDB in 2011. He studied at the Belmonte Lab in the Salk Institute from 2012 to 2014.

Currently, he is an Associate Professor of Cardiovascular Surgery in Osaka University, Japan. His interest is regenerative medicine using iPS-derived cells, including molecular targeted therapy for iPS-derived undifferentiated cells to improve safety.

  • Iseoka H, Miyagawa S, Fukushima S, Saito A, Masuda S, Yajima S, Ito E, Sougawa N, Takeda M, Harada A, Lee JK, Sawa Y. Pivotal role of non-cardiomyocytes in electromechanical and therapeutic potential of induced pluripotent stem cell-derived engineered cardiac tissue. Tissue Eng Part A. 24(3-4): 287-300, 2018.
  • Masuda S. Atherosclerosis: Caused by Mutated Old Blood Cells. [Editorial] Ann Cardiol Cardiovasc Med. 1(1): 1002, 2017.
  • Masuda S, Miyagawa S, Sawa Y. A Highly Durable RNAi Therapeutic Inhibitor of PCSK9. N Engl J Med. 376(18): e38, 2017.
  • Masuda S, Miyagawa S, Nakamura T, Khurram MA, Sawa Y. Brentuximab vedotin for CD30-positive tumours. Lancet Oncol. 17(9): e371, 2016.
  • Masuda S, Miyagawa S, Fukushima S, Nakamura T, Khurram MA, Ishikawa T, Saito A, Sawa Y. Expandable progenitors from induced pluripotent stem cells. Nat Rev Cardiol. 13(10): 574, 2016.
  • Miyagawa S, Fukushima S, Imanishi Y, Kawamura T, Mochizuki-Oda N, Masuda S, Sawa Y. Building a new treatment for heart failure-Transplantation of Induced Pluripotent Stem Cell-derived Cells into the Heart. Curr Gene Ther. 16(1): 5-13, 2016.
  • Kawamura A, Miyagawa S, Fukushima S, Kawamura T, Kashiyama N, Ito E, Watabe T, Masuda S, Toda K, Hatazawa J, Morii E, Sawa Y. Teratocarcinomas Arising from Allogeneic Induced Pluripotent Stem Cell-Derived Cardiac Tissue Constructs Provoked Host Immune Rejection in Mice. Sci Rep. 6: 19464, 2016.
  • Masuda S, Miyagawa S, Fukushima S, Sougawa N, Okimoto K, Tada C, Saito A, Sawa Y. Eliminating residual iPS cells for safety in clinical application. Protein Cell. 6(7): 469-471, 2015.
  • Masuda S, Miyagawa S, Fukushima S, Sougawa N, Okimoto K, Saito A, Sawa Y. CD30-targeting immunoconjugates and bystander effects. Nat Rev Clin Oncol. 12(4): 245, 2015.
  • Masuda S, Miyagawa S, Fukushima S, Kawamura T, Kashiyama N, Saito A, Sawa Y. Regulating ES or Induced Pluripotent Stem Cells by Innate Lymphoid Cells. Transplantation. 98(5): e38-e39, 2014.
  • Liu GH, Suzuki K, Li M, Qu J, Montserrat N, Tarantino C, Gu Y, Yi F, Xu X, Zhang W, Ruiz S, Plongthongkum N, Zhang K, Masuda S, Nivet E, Tsunekawa Y, Soligalla RD, Goebl A, Aizawa E, Kim NY, Kim J, Dubova I, Li Y, Ren R, Benner C, del Sol A, Bueren J, Trujillo JP, Surralles J, Cappelli E, Dufour C, Esteban CR, Izpisua Belmonte JC. Modelling Fanconi Anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs. Nat Commun. 5: 4330, 2014.
  • Masuda S, Miyagawa S, Fukushima S, Sougawa N, Ito E, Takeda M, Saito A, Sawa Y. Emerging innovation towards safety in the clinical application of ESCs and iPSCs. Nat Rev Cardiol. 11(9): 553-554, 2014.
  • Masuda S, Izpisua Belmonte JC. A recipe for targeted therapy in prostate cancer. Nat Rev Urol. 11(7): 419-420, 2014.
  • Masuda S, Izpisua Belmonte JC. Re: Serum miR-21 as a Diagnostic and Prognostic Biomarker in Colorectal Cancer. J Natl Cancer Inst. 106(3): djt457, 2014.
  • Masuda S, Wu J, Hishida T, Pandian GN, Sugiyama H, Izpisua Belmonte JC. Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach. J Mol Cell Biol. 5(5): 354-355, 2013.
  • Masuda S, Suzuki K, Izpisua Belmonte JC. Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. N Engl J Med. 369(12): 1170-1172, 2013.
  • Li M, Kim NY, Masuda S, Izpisua Belmonte JC. Regulation of somatic stem cell function by DNA methylation and genome imprinting. Cell Tissue Transplant Ther. 5: 19–23, 2013.
  • Masuda S. A putative link among the triad: inflammation, reprogramming, and cancer. [Editorial] J Tumor. 1(2): 5-6, 2013.
  • Masuda S, Izpisua Belmonte JC. The microenvironment and resistance to personalized cancer therapy. Nat Rev Clin Oncol. 10(2): 79, 2013.
  • Masuda S, Izpisua Belmonte JC. At the crossroads of targeted treatment and resistance in melanoma. Lancet Oncol. 14(4): e136-e137, 2013.
  • Masuda S, Li M, Izpisua Belmonte JC. Niche-less maintenance of HSCs by 2i. Cell Res. 23(4): 458-459, 2013.
  • Masuda S, Izpisua Belmonte JC. Cotransplantation of MSCs and HSCs. Transplantation. 95(10): e62-e63, 2013.
  • Masuda S, Li M, Izpisua Belmonte JC. In vitro generation of platelets through direct conversion: first report in My Knowledge (iMK). Cell Res. 23(2): 176-178, 2013.
  • Masuda S, Montserrat N, Okamura D, Suzuki K, Izpisua Belmonte JC. Cardiosphere-derived cells for heart regeneration. Lancet. 379(9835): 2425-2426, 2012.
  • Masuda S, Izpisua Belmonte JC. Trametinib for patients with advanced melanoma. Lancet Oncol. 13(10): e409, 2012.
  • Masuda S, Yokoo T, Sugimoto N, Doi M, Fujishiro S, Takeuchi K, Kobayashi E, Hanazono Y. A simplified in vitro teratoma assay for pluripotent stem cells injected into rodent fetal organs. Cell Med. 3(1): 103-112, 2012.
  • Masuda S. Cardiac stem cells in patients with ischaemic cardiomyopathy. Lancet. 379(9819): 891-892, 2012.
  • Abe T, Masuda S, Tanaka Y, Nitta S, Kitano Y, Hayashi S, Hanazono Y, Nagao Y. Maternal Administration of Busulfan Before in Utero Transplantation of Human Hematopoietic Stem Cells Enhances Engraftments in Sheep. Exp Hematol. 40(6): 436-444, 2012.
  • Masuda S. Regulatory T cells in Graft-versus-Host Disease. N Engl J Med. 366(10): 962-963, 2012.
  • Masuda S. Re: Delta-Like Ligand 4-Notch Blockade and Tumor Radiation Response. J Natl Cancer Inst. 104(5): 421-422, 2012.
  • Masuda S. Risk of teratoma formation after transplantation of induced pluripotent stem cells. Chest. 141(4): 1120-1121, 2012.
  • Masuda S. Dysfunctional transforming growth factor-ß signaling with constitutively active Notch signaling in Barrett's esophageal adenocarcinoma. Cancer. 118(7): 1957-1958, 2012.
  • Masuda S, Hayashi S, Ageyama N, Shibata H, Abe T, Nagao Y, Hanazono Y. Migration of cells from the yolk sac to hematopoietic tissues after in utero transplantation of early and mid gestation canine fetuses. Transplantation. 92(2): e5-6, 2011.
  • Masuda S. Cord colitis syndrome in cord-blood stem-cell transplantation. N Engl J Med. 365(24): 2336-2338, 2011.
  • Masuda S. Point mutations in myelodysplastic syndromes. N Engl J Med. 365(12): 1154-1155, 2011.
  • Masuda S. Evidence for human lung stem cells. N Engl J Med. 365(5): 464-465, 2011.
  • Masuda S. More on NK-cell and B-cell deficiency with a thymic mass. N Engl J Med. 364(20): 1979-1981, 2011.
  • Masuda S, Hanazono Y. Induced pluripotent stem cells in long-QT syndrome. N Engl J Med. 364(2): 181-182, 2011.
  • Abe T, Masuda S, Ban H, Hayashi S, Ueda Y, Inoue M, Hasegawa M, Nagao Y, Hanazono Y. Ex vivo expansion of human HSCs with Sendai virus vector expressing HoxB4 assessed by sheep in utero transplantation. Exp Hematol. 39(1):47-54, 2011.
  • Masuda S. Leukemic stem cell gene expression signature and clinical outcomes in acute myeloid leukemia. JAMA. 305(11): 1094-1095, 2011.
  • Masuda S. DNMT3A mutations in acute myeloid leukemia: impact on low risk patients with CEBPA mutations. J Clin Oncol. 29(34): 4592-4593, 2011.
  • Masuda S. Notch1 and Notch2 have opposite prognostic effects on patients with colorectal cancer. Ann Oncol. 22(11): 2533-2534, 2011.
  • Tanaka Y, Masuda S, Abe T, Hayashi S, Kitano Y, Nagao Y, Hanazono Y. Intravascular route is not superior to an intraperitoneal route for in utero transplantation of human hematopoietic stem cells and engraftment in sheep. Transplantation. 90(4): 462-463, 2010.
  • Masuda S, Ageyama N, Shibata H, Obara Y, Ikeda T, Takeuchi K, Ueda Y, Ozawa K, Hanazono Y. Cotransplantation with MSCs improves engraftment of HSCs after autologous intra-bone marrow transplantation in nonhuman primates. Exp Hematol. 37(10): 1250-1257, 2009.
  • Masuda S, Kumano K, Suzuki T, Tomita T, Iwatsubo T, Natsugari H, Tojo A, Shibutani M, Mitsumori K, Hanazono Y, Ogawa S, Kurokawa M, Chiba S. Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model. Cancer Sci. 100(12): 2444-2450, 2009.
  • Haraguchi K, Suzuki T, Koyama N, Kumano K, Nakahara F, Matsumoto A, Yokoyama Y, Sakata-Yanagimoto M, Masuda S, Takahashi T, Kamijo A, Takahashi K, Takanashi M, Okuyama Y, Yasutomo K, Sakano S, Yagita H, Kurokawa M, Ogawa S, Chiba S. Notch activation induces the generation of functional natural killer cells from human cord blood CD34-positive cells devoid of interleukin-15. J Immunol. 182(10): 6168-6178, 2009.
  • Tanaka Y, Ikeda T, Kishi Y, Masuda S, Shibata H, Takeuchi K, Komura M, Iwanaka T, Muramatsu S, Kondo Y, Takahashi K, Yamanaka S, Hanazono Y. ERas is expressed in primate embryonic stem cells but not related to tumorigenesis. Cell Transplant. 18(4): 381-389, 2009.
  • Kumano K, Masuda S, Sata M, Saito T, Lee SY, Sakata-Yanagimoto M, Tomita T, Iwatsubo T, Natsugari H, Kurokawa M, Ogawa S, Chiba S. Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis. Pigment Cell Melanoma Res. 21(1): 70-78, 2008.
  • Kishi Y, Tanaka Y, Shibata H, Nakamura S, Takeuchi K, Masuda S, Ikeda T, Muramatsu S, Hanazono Y. Variation in the incidence of teratomas after the transplantation of non-human primate ES cells into immunodeficient mice. Cell Transplant. 17(9): 1095-1102, 2008.
  • Kishi Y, Inoue M, Tanaka Y, Shibata H, Masuda S, Ikeda T, Hasegawa M, Hanazono Y. Knockout Serum Replacement (KSR) has a suppressive effect on Sendai virus-mediated transduction of cynomolgus ES cells. Cloning Stem Cells. 10(3): 307-312, 2008.
  • Tanaka Y, Nakamura S, Shibata H, Kishi Y, Ikeda T, Masuda S, Sasaki K, Abe T, Hayashi S, Kitano Y, Nagao Y, Hanazono Y. Sustained macroscopic engraftment of cynomolgus embryonic stem cells in xenogeneic large animals after in utero transplantation. Stem Cells Dev. 17(2): 367-381, 2008.
  • Masuda S. The molecular mechanism of Notch-induced transformation and therapeutic potential of its inhibitor. Rinsho Ketsueki. 47(7): 557-563, 2006.
  • Masuda S, Kumano K, Shimizu K, Imai Y, Kurokawa M, Ogawa S, Miyagishi M, Taira K, Hirai H, Chiba S. Notch1 oncoprotein antagonizes TGF-beta/Smad-mediated cell growth suppression via sequestration of coactivator p300. Cancer Sci. 96(5): 274-282, 2005.
  • Lee SY, Kumano K, Masuda S, Hangaishi A, Takita J, Nakazaki K, Kurokawa M, Hayashi Y, Ogawa S, Chiba S. Mutations of the Notch1 gene in T-cell acute lymphoblastic leukemia:analysis in adults and children. Leukemia. 19: 1841-1843, 2005.
  • Ohmatsu H, Saeki H, Fujita H, Toyoma K, Sugaya M, Asahina A, Masuda S, Hirai H, Watanabe T, Nagawa H, Tamaki K. Mycosis fungoides associated with intestinal mucosa-associated lymphoid tissue lymphoma. Int J Dermatol. 44(10): 878-880, 2005.
  • Chiba S, Takeshita K, Imai Y, Kumano K, Kurokawa M, Masuda S, Shimizu K, Nakamura S, Ruddle FH,Hirai H. Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells. Proc Natl Acad Sci U S A. 100(26): 15577-15582, 2003.
  • Kunisato A, Chiba S, Nakagami-Yamaguchi E, Kumano K, Saito T, Masuda S, Yamaguchi T, Osawa M, Kageyama R, Nakauchi H, Nishikawa M, Hirai H. HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo. Blood. 101(5): 1777-1783, 2003.
  • Kumano K, Chiba S, Kunisato A, Sata M, Saito T, Nakagami-Yamaguchi E, Ymaguchi T, Masuda S, Shimizu K, Takahashi T, Ogawa S, Hamada Y, Hirai H. Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells. Immunity. 18(5): 699-711, 2003.
  • Chiba S, Saito A, Ogawa S, Takeuchi K, Kumano K, Seo S, Suzuki T, Tanaka Y, Saito T, Izutsu K, Yuji K, Masuda S, Futami S, Nishida M, Suzuki G, Gale RP, Fukayama M, Maekawa K, Hirai H. Transplantation for accidental acute high-dose total body neutron- and gamma-radiation exposure. Bone Marrow Transplant. 29(11): 935-939, 2002.
  • Tanaka Y, Takahashi T, Nieda M, Masuda S, Kashiwase K, Takahashi T, Ogawa S, Chiba S, Juji T, Hirai H. Generation of Fas-independent CD4+ cytotoxic T-cell clone specific for p190 minor bcr-abl fusion peptide. Leuk Res. 26(3): 317-321, 2002.
  • Horikoshi M, Machida U, Itikawa M, Seo S, Masuda S, Kurokawa M, Ogawa S, Sunaga S, Honda H, Aoki K, Chiba S, Mitani K, Hirai H, Yazaki Y. Essential thrombocythemia in transformation from myelodysplastic syndrome to acute myeloid leukemia with inv(3) after treatment for gastric cancer. Rinsho Ketsueki. 41(1): 68-71, 2000.
  • Tanaka Y, Takahashi T, Nieda M, Masuda S, Kashiwase K, Ogawa S, Chiba S, Juji T, Hirai H. Generation of HLA-DRB1*1501-restricted p190 minor bcr-abl (e1a2)-specific CD4+ T lymphocytes. Br J Haematol. 109(2): 435-437, 2000.

Award

  • 2011: Japan Society of Gene Therapy Award (the Japan Society of Gene Therapy)
  • 2010: Young Investigator’s Award (the Japanese Society for Regenerative Medicine)
  • 2007: Incitement Award (the Japanese Cancer Association)
  • 2005: Incitement Award (the Japanese Society of Hematology)
  • 2005: Young Investigator’s Award (the Japan Prize Foundation)

Patent

International Application No. PCT/ JP2015/081408; Filed on November 6, 2015; Applicant: OSAKA UNIVERSITY.

Grants from Japanese Government

  • Masuda S : Grant-in-Aid for Scientific Research (C) from MEXT of Japan,2015-18.
  • Masuda S : Grant-in-Aid for Young Scientists (B) from MEXT of Japan, 2011-12.
  • Masuda S : Grant-in-Aid for Young Scientists (B) from MEXT of Japan, 2009-11.
  • Masuda S : Grant-in-Aid for Young Scientists (B) from MEXT of Japan, 2007-09.
  • Masuda S : Grant-in-Aid for Young Scientists (B) from MEXT of Japan, 2005-07.
  • Masuda S : Travel Award from Grant-in-Aid for Scientific Research on Priority Areas, 2006.

Grants from Private Foundations

  • Masuda S : Research funding from SENSHIN Medical Research Foundation, 2017.
  • Masuda S : Research funding from Japanese Society of Hematology, 2017.
  • Masuda S : Research funding from Magobee Kobayashi Foundation, 2017.
  • Masuda S : Research funding from the Ichiro Kanehara Foundation, 2016.
  • Masuda S : Research funding from Daiwa Securities Health Foundation, 2016.
  • Masuda S : Research funding from Hyogo Science and Technology Association, 2016.
  • Masuda S : Research funding from Astellas Foundation for Research on Metabolic Disorders, 2015.
  • Masuda S : Research funding from Mochida Memorial Foundation for Medical and Pharmaceutical Research, 2015.
  • Masuda S : Research funding from Takeda Science Foundation, 2015.
  • Masuda S : Research funding from Kudo Foundation, 2015.
  • Masuda S : Research funding from Kobayashi Foundation for Cancer Research, 2015.
  • Masuda S : Research funding from the Osaka Community Foundation, 2015.
  • Masuda S : Research funding from the Ichiro Kanehara Foundation, 2015.
  • Masuda S : Research funding from Suzuken Memorial Foundation, 2014.
  • Masuda S : Overseas funding from Mochida Memorial Foundation for Medical and Pharmaceutical Research, 2012.
  • Masuda S : Overseas funding from Kanzawa Medical Research Foundation, 2012.
  • Masuda S : Overseas funding from the Yasuda Medical Foundation, 2012.
  • Masuda S : Watanabe Special Incitement Award from the UBE Foundation, 2011.
  • Masuda S : Research funding from Kowa Life Science Foundation, 2011.
  • Masuda S : Research funding from Daiwa Securities Health Foundation, 2010.
  • Masuda S : Research funding from Mitsubishi Pharma Research Foundation, 2010.
  • Masuda S : Research funding from Osaka Gan Kenkyukai, 2010.
  • Masuda S : Research funding from Takeda Science Foundation, 2009.
  • Masuda S : Research funding from Mochida Memorial Foundation for Medical and Pharmaceutical Research, 2009.
  • Masuda S : Research funding from the Japan Leukemia Research Fund, 2009.
  • Masuda S : Research funding from the Ichiro Kanehara Foundation, 2009.
  • Masuda S : Research funding from the Yasuda Medical Foundation, 2009.
  • Masuda S : Research funding from Takeshi Nagao Foundation, 2009.
  • Masuda S : Research funding from Okinaka Memorial Foundation, 2009.
  • Masuda S : Research funding from the Uehara Memorial Foundation, 2009.
  • Masuda S : Jichi Medical University Young Investigator Award, 2008.
  • Masuda S : Research funding from Kawano Masanori Memorial Foundation. for Promotion of Pediatrics, 2008.
  • Masuda S : Research funding from Aichi Cancer Research Foundation, 2008.
  • Masuda S : Research funding from the Ichiro Kanehara Foundation, 2008.
  • Masuda S : Research funding from Kanae Foundation for the Promotion of Medical Science, 2008.
  • Masuda S : Research funding from Mitsubishi Pharma Research Foundation, 2008.
  • Masuda S : Research funding from Aichi Cancer Research Foundation, 2007.
  • Masuda S : Research funding from Japan Intractable Diseases Research Foundation, 2007.
  • Masuda S : Research funding from Suzuken Memorial Foundation, 2007.
  • Masuda S : Research funding from Takeshi Nagao Foundation, 2007.
  • Masuda S : Research funding from Kanzawa Medical Research Foundation, 2007.
  • Masuda S : Research funding from Aichi Cancer Research Foundation, 2006.
  • Masuda S : KYO award from the Japan Leukemia Research Fund, 2005.
  • Masuda S : Young Investigator’s Award from the Japan Prize Foundation, 2005.

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